中国体外生命支持2026，Vol.24Issue(4)：337-341,5.DOI:10.13498/j.cnki.chin.j.ecls.2026.04.12
血浆游离血红蛋白与部分凝血活酶时间联合评价血泵机械溶血的研究
Combined Assessment of Plasma Free Hemoglobin and Partial Thromboplastin Time for Evaluating Mechanical Hemoly-sis in Blood Pumps
摘要
Abstract
Objective To investigate the dynamic relationship between plasma free hemoglobin(PFH)and partial thromboplastin time(PTT)during blood pump circulation,and to establish a more comprehensive evaluation method for me-chanical hemolysis.Methods To simulate clinical application of blood pumps,an extracorporeal blood circulation circuit was established using fresh anticoagulated bovine blood.PFH and PTT were measured at 1,2,3,4,5,and 6 h under various pump flow rates.Results PFH showed a positive correlation with increasing pump flow rates and circulation duration,whereas PTT showed a negative correlation.Spearman rank correlation analysis revealed a strong negative correlation between PFH and PTT(r=-0.78,P<0.001).Conclusion Mechanical force-induced hemolysis in blood pumps is associated with a consistent and sta-ble negative correlation between elevated PFH and shortened PTT.Although a direct causal relationship cannot be established,simultaneous monitoring of PFH and PTT may provide a more comprehensive identification of blood injury risks during extra-corporeal circulation and improve the hemocompatibility evaluation of blood pump medical devices.关键词
医疗器械/血泵/机械溶血/血浆游离血红蛋白/部分凝血活酶时间/血液相容性Key words
medical devices/blood pumps/mechanical hemolysis/plasma free hemoglobin/partial thromboplastin time/hemocompatibility引用本文复制引用
莫晓彦,柯军,徐苏华,吴雅琳,郝文茜,叶嘉莉,杨文润..血浆游离血红蛋白与部分凝血活酶时间联合评价血泵机械溶血的研究[J].中国体外生命支持,2026,24(4):337-341,5.基金项目
广东省药品监督管理局科技创新项目(2026TDZ33) （2026TDZ33）
