遵义医科大学学报2026，Vol.49Issue(8)：832-839,8.
缰核中星形胶质细胞在异氟烷麻醉致意识改变中的作用
Role of habenular astrocytes in isoflurane-induced consciousness alterations
摘要
Abstract
Objective To explore the role of astrocytes in the habenula(Hb)area in the alteration of conscious-ness caused by isoflurane anesthesia.Methods By injecting specific viruses into the Hb region of mice,the fol-lowing two groups of models were constructed:the group with astrocyte inhibition,and the activation group.Be-havioral tests were conducted to detect the disappearance and recovery time of the righting reflex in mice under isoflurane effect,and simultaneous electroencephalogram was recorded;the accuracy of the virus injection target was verified by immunofluorescence,and the changes in neuronal activity were detected by immunohistochemis-try.Results The immunohistochemical results showed that during the maintenance period of isoflurane anesthe-sia,the activity of astrocytes in the Hb area decreased;while during the recovery period,their activity signifi-cantly increased.The behavioral results indicated that inhibiting the astrocytes in the Hb area could accelerate the recovery from anesthesia,while activating these cells would delay the recovery.Conclusion The activation and inhibition of astrocytes in the Hb region can regulate the anesthesia awakening time in both directions.关键词
缰核/星形胶质细胞/异氟烷/麻醉/意识改变Key words
habenula/astrocyte/isoflurane/anesthesia/change of consciousness分类
医药卫生引用本文复制引用
陈文佳,卢娅丽,柯志丹,罗鑫雅,周亮..缰核中星形胶质细胞在异氟烷麻醉致意识改变中的作用[J].遵义医科大学学报,2026,49(8):832-839,8.基金项目
国家自然科学基金资助项目(NO:82460242). （NO:82460242）
