摘要
Abstract
Objective This study performed a quantitative analysis of left ventricular myocardial strain in mitral valve disease(MVD)patients using CMR-FT,and further assessed the technique's value for early functional e-valuation.Methods A total of 75 patients with MVD who underwent 3.0T cardiac magnetic resonance examina-tion at West China Hospital,Sichuan University,from September 2014 to March 2020 were retrospectively re-viewed.56 patients with isolated MVD were finally enrolled,including 27 patients with mitral stenosis(MS)and 29 patients with mitral regurgitation(MR).In addition,32 age-and sex-matched healthy volunteers were in-cluded as the control group.All participants underwent CVI42-based post-processing analysis.Left ventricular functional parameters,including left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),and myocardial strain indices in radial,circumferen-tial,and longitudinal directions,were obtained.Results Compared with the control group,patients with MR showed significantly increased LVEDV[(181.15±82.21)ml vs(124.16±22.65)ml],whereas patients with MS showed significantly reduced values[(100.95±32.19)ml](P<0.05).Both the MS and MR groups showed significantly reduced LVEF compared with the control group(P<0.05).Global strain parameters were significantly reduced in both mitral stenosis(MS)and mitral regurgitation(MR)patients compared with healthy controls.Specifically,global peak longitudinal strain was significantly lower in the MS and MR groups[(-12.76±4.16)%and(-12.53±2.89)%,respectively]than in the control group[(-17.28±2.52)%,P<0.05].In patients with preserved LVEF,strain parameters remained significantly lower than those in the control group(P<0.05).Correlation analysis demonstrated that global strain parameters in MR patients were signifi-cantly associated with LVEF,New York Heart Association functional class,and regurgitant volume(P<0.05).Conclusion CMR-FT may sensitively detect early left ventricular functional abnormalities in patients with MVD and identify subclinical myocardial contractile impairment despite preserved LVEF.It may also provide additional information for disease severity assessment and clinical decision-making regarding intervention timing.关键词
心血管磁共振/特征追踪/二尖瓣疾病/左心室重构/心肌应力Key words
cardiovascular magnetic resonance/feature tracking technique/mitral valve disease/left ventricu-lar remodeling/myocardial strain分类
医药卫生
