遵义医科大学学报2026，Vol.49Issue(8)：905-919,15.
靶向细胞衰老重塑炎性微环境促进牙周组织再生的研究进展
Research progress on targeting cellular senescence to remodel the inflammato-ry microenvironment and promote periodontal tissue regeneration
摘要
Abstract
Periodontitis is a chronic infectious inflammatory disease mediated by dental plaque biofilms and characterized by progressive destruction of the periodontal supporting tissues.Although conventional therapies can effectively control infection and inflammation,achieving predictable functional periodontal regeneration re-mains a major challenge.Increasing evidence indicates that cellular senescence plays a critical role in microen-vironmental imbalance and impaired regenerative capacity in periodontitis.Multiple factors,including bacterial virulence factors,oxidative stress,abnormal mechanical loading,aging,and diabetes,can induce senescence in periodontal ligament stem cells,gingival epithelial cells,gingival fibroblasts,bone-related cells,and immune cells.Through the senescence-associated secretory phenotype,senescent cells perpetuate inflammation,acceler-ate extracellular matrix degradation,disrupt bone homeostasis,and trigger bystander senescence,thereby form-ing a vicious cycle that is unfavorable for periodontal repair.Targeting cellular senescence has therefore emerged as a promising therapeutic strategy.Senolytics selectively eliminate senescent cells,whereas senomorphics sup-press the senescence-associated secretory phenotype and modulate senescence-related phenotypes.Both approa-ches have shown potential in improving the periodontal inflammatory microenvironment,reducing tissue destruc-tion,and enhancing tissue regeneration.This review summarizes the inducing factors,major target cells,patho-genic mechanisms,and intervention strategies of cellular senescence in periodontitis,aiming to provide new in-sights into periodontal regenerative therapy.关键词
牙周炎/细胞衰老/衰老细胞清除剂/衰老表型调节剂Key words
periodontitis/cellular senescence/senolytics/senomorphics分类
医药卫生引用本文复制引用
李敏,高明权,张纲..靶向细胞衰老重塑炎性微环境促进牙周组织再生的研究进展[J].遵义医科大学学报,2026,49(8):905-919,15.基金项目
国家自然科学青年基金资助项目(NO:82404198) （NO:82404198）
高原医学研究中心自主科研重点资助项目(NO:24GYZXMS05). （NO:24GYZXMS05）
