遵义医科大学学报2026，Vol.49Issue(8)：920-928,9.
囊虫病基因工程疫苗的研究进展
Research progress of genetic engineering vaccine against cysticercosis
摘要
Abstract
Cysticercosis,caused by the cestode Taenia solium,is a zoonotic parasitic disease listed by the WHO as one of the 20 neglected tropical diseases and remains a priority for control and elimination in China.Vaccination represents the most cost-effective strategy for interrupting disease transmission;however,current vaccines face substantial challenges regarding optimization of antigen selection,mechanistic elucidation,and clinical translation.This review systematically summarizes recent advances in genetic engineering vaccines a-gainst cysticercosis,including recombinant live bacterial vaccines,recombinant subunit vaccines,DNA vac-cines,multi-epitope vaccines,and novel vaccine platforms.We critically analyze the immunoprotective mecha-nisms,advantages,and limitations of each strategy,and identify critical gaps in current research,including the predominant focus on vaccine construction over standardized efficacy evaluation,inadequate animal models,and lack of defined correlation of protection.关键词
猪带绦虫/囊虫病/基因工程疫苗/重组活菌疫苗/DNA疫苗/多表位疫苗/免疫保护机制Key words
Taenia solium/cysticercosis/genetic engineering vaccine/recombinant live bacterial vaccine/DNA vaccine/multi-epitope vaccine/immunoprotective mechanism分类
医药卫生引用本文复制引用
刘美辰,耿伉,周必英..囊虫病基因工程疫苗的研究进展[J].遵义医科大学学报,2026,49(8):920-928,9.基金项目
国家自然科学基金资助项目(NO:82460402) （NO:82460402）
贵州省科技计划项目[NO:黔科合基础MS(2025)355] （2025）
遵义医科大学大学生创新创业训练计划项目(NO:ZYDC202301068). （NO:ZYDC202301068）
