中国造纸2026，Vol.45Issue(8)：77-94,18.DOI:10.11980/j.issn.0254-508X.2026.08.009
纸基血型检测芯片的研究进展及展望
Research Progress and Prospect of Paper-based Blood Typing Chips
摘要
Abstract
Paper-based blood typing detection chips miniaturize the traditional hemagglutination reaction into a porous cellulose medium sys-tem.Relying on the capillary driving effect of paper substrates,they realize autonomous transport of trace blood samples and specific anti-gen-antibody binding.Combined with colorimetric or electrochemical detection technologies,blood types can be rapidly identified,making this a highly promising research direction of paper-based microfluidic devices in transfusion medicine.This paper systematically reviewed the substrate types,detection principles and signal readout modes of such chips,elaborateed the formation mechanisms of false positives and false negatives,summarized the residual adsorption issue of unagglutinated red blood cells and corresponding solutions,and analyzed the regulatory mechanism of fiber physicochemical structures on the transport and adsorption behaviors of red blood cells.关键词
纸基血型检测芯片/血凝反应/假阳性判读/非特异性吸附/纤维素基材Key words
paper-based blood typing chip/hemagglutination reaction/false positive interpretation/non-specific adsorption/cellulose substrate分类
轻工纺织引用本文复制引用
张雪,杜凡,李丽君,陈雪梅,杨光照,高杰,张时通,田超..纸基血型检测芯片的研究进展及展望[J].中国造纸,2026,45(8):77-94,18.基金项目
国家特殊海外高层次人才计划项目 （）
国家自然科学基金(32001276) （32001276）
制浆造纸国家工程实验室基金(ZZY2025JBGS04). （ZZY2025JBGS04）
