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One-pot asymmetric synthesis of chiral vicinal diols utilizing novel benzaldehyde lyases and carbonyl reductases

Xianqi Yin Shenggan Luo Xinyue Xie Yuanzhen Zhang Lin Chen Rubing Liang Ting Shi Jian Li Shuangjun Lin

Green Synthesis and Catalysis2026，Vol.7Issue(3)：P.308-316,9.

Green Synthesis and Catalysis2026，Vol.7Issue(3)：P.308-316,9.DOI:10.1016/j.gresc.2025.06.002

One-pot asymmetric synthesis of chiral vicinal diols utilizing novel benzaldehyde lyases and carbonyl reductases

Xianqi Yin ¹Shenggan Luo ¹Xinyue Xie ¹Yuanzhen Zhang ¹Lin Chen ¹Rubing Liang ¹Ting Shi ¹Jian Li ²Shuangjun Lin³

作者信息

1. State Key Laboratory of Microbial Metabolism,Joint International Research Laboratory on Metabolic&Developmental Sciences,School of Life Sciences&Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China
2. Frontiers Science Center for Transformative Molecules,School of Chemistry and Chemical Engineering,Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs and Zhangjiang Institute for Advanced Study,Shanghai Jiao Tong University,Shanghai 200240,China
3. State Key Laboratory of Microbial Metabolism,Joint International Research Laboratory on Metabolic&Developmental Sciences,School of Life Sciences&Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China Haihe Laboratory of Synthetic Biology,Tianjin 300308,China Frontiers Science Center for Transformative Molecules and Zhangjiang Institute for Advanced Study,Shanghai Jiao Tong University,Shanghai 200240,China
折叠

摘要

关键词

Chiral vicinal diols/Enzyme mining strategy/Benzaldehyde lyase/Carbonyl reductase/Stereospecificity

分类

化学化工

引用本文复制引用

Xianqi Yin,Shenggan Luo,Xinyue Xie,Yuanzhen Zhang,Lin Chen,Rubing Liang,Ting Shi,Jian Li,Shuangjun Lin..One-pot asymmetric synthesis of chiral vicinal diols utilizing novel benzaldehyde lyases and carbonyl reductases[J].Green Synthesis and Catalysis,2026,7(3):P.308-316,9.

基金项目

supported by grants from the National Key Research and Development Program of China(No.2023YFA1506700) （No.2023YFA1506700）

Shanghai Municipal Science and Technology Major Project,the‘Major Project’of Haihe Laboratory of Synthetic Biology(No.22HHSWSS00001) （No.22HHSWSS00001）

the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(No.TSBICIP-CXRC-065). （No.TSBICIP-CXRC-065）

Green Synthesis and Catalysis

ISSN：2666-5549

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