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SARS-CoV-2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release

Fujun Qin Chuang Yan Zizheng Liu Dianbing Wang Huimin Zhong Qiang Ding Minghai Chen Xian-En Zhang

mLife2026，Vol.5Issue(3)：P.339-354,16.

mLife2026，Vol.5Issue(3)：P.339-354,16.DOI:10.1002/mlf2.70065

SARS-CoV-2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release

Fujun Qin ¹Chuang Yan ¹Zizheng Liu ²Dianbing Wang ²Huimin Zhong ¹Qiang Ding ³Minghai Chen ¹Xian-En Zhang⁴

作者信息

1. State Key Laboratory of Quantitative Synthetic Biology,Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China
2. State Key Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing,China
3. School of Medicine,Tsinghua University,Beijing,China
4. Faculty of Synthetic Biology,Shenzhen University of Advanced Technology,Shenzhen,China State Key Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing,China
折叠

摘要

关键词

lysosomal exocytosis/lysosome deacidification/ORF3a protein/SARS-CoV-2/synthetic biology

分类

医药卫生

引用本文复制引用

Fujun Qin,Chuang Yan,Zizheng Liu,Dianbing Wang,Huimin Zhong,Qiang Ding,Minghai Chen,Xian-En Zhang..SARS-CoV-2 enhances lysosomal exocytosis and deacidifies lysosomes to facilitate viral release[J].mLife,2026,5(3):P.339-354,16.

基金项目

supported by the National Key R&D Program of China(Grant No.2022YFC2303500) （Grant No.2022YFC2303500）

the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB29050100) （Grant No.XDB29050100）

the National Natural Science Foundation of China(Grant Nos.32100121,32101210,and 21890743). （Grant Nos.32100121,32101210,and 21890743）

mLife

ISSN：2097-1699

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