Reengineering immunotherapeutic responses:ferroptosis-primed radiotherapy converts cold-colorectal tumors into immunotherapy checkpoint inhibitor-sensitive hot lesions
Hang Jia Le-Qi Zhou Rong-Bo Wen Yue Yu Ning Wang Tian-Shuai Zhang Zhi-Ying Peng Jian-Feng Chen Guan-Yu Yu Wei Zhang
Reengineering immunotherapeutic responses:ferroptosis-primed radiotherapy converts cold-colorectal tumors into immunotherapy checkpoint inhibitor-sensitive hot lesions
摘要
关键词
Colorectal cancer(CRC)/Ionizing radiation(IR)/Immunotherapy checkpoint inhibitor(ICI)/Ferroptosis/Tumor immune/Tumor microenvironment(TME)分类
医药卫生引用本文复制引用
Hang Jia,Le-Qi Zhou,Rong-Bo Wen,Yue Yu,Ning Wang,Tian-Shuai Zhang,Zhi-Ying Peng,Jian-Feng Chen,Guan-Yu Yu,Wei Zhang..Reengineering immunotherapeutic responses:ferroptosis-primed radiotherapy converts cold-colorectal tumors into immunotherapy checkpoint inhibitor-sensitive hot lesions[J].LabMed Discovery,2026,3(1):P.23-32,10.基金项目
financially supported by grants from the National Natural Science Foundation of China(Nos.82272705 and 82203137) （Nos.82272705 and 82203137）
the Shanghai“Rising Stars of Medical Talents”Youth Development Program of the Shanghai Municipal Health Commission,China(No.2024-70) （No.2024-70）
the Naval Medical University“Deep Blue”Project Talent Program,the First Affiliated Hospital of Naval Medical University Special Project for Basic Medical Research,China(Nos.2023QD003 and 2023PY04) （Nos.2023QD003 and 2023PY04）
the First Affiliated Hospital of Naval Medical University Special Project for Clinical Research,China(No.2024LYA02) （No.2024LYA02）
the Health Care Research Project 2024,China(No.24BJZ10) （No.24BJZ10）
the Commission Health Industry Clinical Research Project of China(No.20224Y0348). （No.20224Y0348）
