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Sleep disorders and blood-brain barrier dysfunction:mechanisms,biomarkers,and therapeutic implications for neurocognitive decline

Mengyao Li Yingni Lin Xixi Chen Ke Huang Junqi Lin Zixuan Hua Xinxin Ran Yiyang Shen Chunli Ban Kexin Xia Qingyun Li

LabMed Discovery2026，Vol.3Issue(2)：P.17-24,8.

LabMed Discovery2026，Vol.3Issue(2)：P.17-24,8.DOI:10.1016/j.lmd.2026.100131

Sleep disorders and blood-brain barrier dysfunction:mechanisms,biomarkers,and therapeutic implications for neurocognitive decline

Mengyao Li ¹Yingni Lin ¹Xixi Chen ¹Ke Huang ¹Junqi Lin ¹Zixuan Hua ¹Xinxin Ran ¹Yiyang Shen ¹Chunli Ban ¹Kexin Xia ¹Qingyun Li¹

作者信息

1. Department of Respiratory and Critical Care Medicine,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China Institute of Respiratory Diseases,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China Shanghai Key Laboratory of Emergency Prevention,Diagnosis and Treatment of Respiratory Infectious Diseases,Shanghai 200025,China
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摘要

关键词

Blood-brain barrier(BBB)/Sleep disorder/Obstructive sleep apnea(OSA)/Insomnia/Sleep deprivation/Neuroinflammation/Cognitive decline/Alzheimer’s disease(AD)

分类

医药卫生

引用本文复制引用

Mengyao Li,Yingni Lin,Xixi Chen,Ke Huang,Junqi Lin,Zixuan Hua,Xinxin Ran,Yiyang Shen,Chunli Ban,Kexin Xia,Qingyun Li..Sleep disorders and blood-brain barrier dysfunction:mechanisms,biomarkers,and therapeutic implications for neurocognitive decline[J].LabMed Discovery,2026,3(2):P.17-24,8.

基金项目

supported by grants from the National Natural Science Foundation of China(Nos.82270100,82470085,82070089,and 81770084) （Nos.82270100,82470085,82070089,and 81770084）

Noncommunicable Chronic Diseases-National Science and Technology Major Project,China(No.2023ZD0506300) （No.2023ZD0506300）

Huangpu District“Glory of Lintel”Talent Program,China(No.RC20240019). （No.RC20240019）

LabMed Discovery

ISSN：3050-4740

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