动物营养学报2026，Vol.38Issue(8)：5609-5619,11.DOI:10.12418/CJAN2026.449
母体三碘甲状腺原氨酸调控胎儿棕色脂肪组织发育的研究进展
Research Progress on Maternal Triiodothyronine in Regulating Fetal Brown Adipose Tissue Development
摘要
Abstract
Brown adipose tissue plays a crucial role in maintaining the body temperature and energy metabolism of young animals through its unique thermogenic function.The development of fetal brown adipose tissue dur-ing the embryonic stage is closely related to the maternal active thyroid hormone triiodothyronine(T3).Mater-nal T3 enters the fetus through the placental transport system and thereby affects the development of fetal brown adipose tissue during pregnancy.T3 promotes the proliferation and directed differentiation of brown adipose pro-genitor cells by binding to thyroid hormone receptors,thereby regulating brown adipose tissue development and controlling mitochondrial biogenesis and homeostasis through genomic and non-genomic pathways,ensuring the thermogenic basis.This article reviews the core role and molecular mechanism of maternal T3 entering the fetus through the placental transport system and influencing the development of fetal brown adipose tissue during the later stages of pregnancy,revealing the developmental rules of fetal brown adipose tissue,and providing an im-portant theoretical basis for nutritional regulation during the later stages of pregnancy in female animals and ear-ly health management of newborn animals.关键词
母体/三碘甲状腺原氨酸/胎儿/棕色脂肪组织发育/产热Key words
maternal/T3/fetal/brown adipose tissue development/thermogenesis分类
生物科学引用本文复制引用
宋健,金晓,孙登生,李昕桐..母体三碘甲状腺原氨酸调控胎儿棕色脂肪组织发育的研究进展[J].动物营养学报,2026,38(8):5609-5619,11.基金项目
国家自然科学基金地区基金项目(32260811) （32260811）
内蒙古自然科学基金项目(2024LHMS03051) （2024LHMS03051）
内蒙古自治区重点研发和成果转化计划(国际科技合作)项目(2024KJHZ0019,2025KJHZ0066) （国际科技合作）
内蒙古自治区高等学校青年科技人才发展项目(NJYT23014) （NJYT23014）
内蒙古自治区直属高校基本科研业务费项目(BR250103) （BR250103）
内蒙古自治区教育厅一流学科科研专项重点项目(YLXKZX-NND-007-11) （YLXKZX-NND-007-11）
