动物营养学报2026，Vol.38Issue(8)：5660-5670,11.DOI:10.12418/CJAN2026.454
抗氧化类益生菌延缓雌性动物卵巢衰老的作用机制与研究进展
Mechanism and Research Progress of Antioxidant Probiotics in Delaying Ovarian Aging in Female Animals
摘要
Abstract
Ovarian aging can lead to decreased fertility,endocrine disorders,and impaired systemic health in female animals.Its pathogenesis is closely associated with oxidative stress,immune inflammation,gut microbi-ota dysbiosis and hypothalamic-pituitary-ovarian axis dysfunction.Antioxidant probiotics,owing to their antiox-idative,anti-inflammatory,and immunomodulatory properties,have become a frontier hotspot for research on delaying ovarian aging.These probiotics can alleviate ovarian inflammation by modulating gut homeostasis,re-pairing the intestinal barrier and reducing the entry of endotoxins into the bloodstream.Simultaneously,they regulate the levels of metabolites such as short-chain fatty acids,scavenge reactive oxygen species,and activate the endogenous antioxidant defense system.Furthermore,they inhibit granulosa cell apoptosis,preserve follicu-lar reserve and improve ovarian function through multiple pathways.This review outlined the core mechanisms of ovarian aging and elaborated on the pathways through which antioxidant probiotics delay ovarian aging in fe-male animals,aiming to provide a reference for related research and applications.关键词
益生菌/雌性动物/卵巢衰老/氧化应激/下丘脑-垂体-卵巢轴Key words
probiotics/female animals/ovarian aging/oxidative stress/hypothalamic-pituitary-ovarian axis分类
农业科技引用本文复制引用
陈美琪,孙梦爽,张晨希,王彦博..抗氧化类益生菌延缓雌性动物卵巢衰老的作用机制与研究进展[J].动物营养学报,2026,38(8):5660-5670,11.基金项目
国家自然科学基金项目(32360182) （32360182）
内蒙古自治区高等学校青年科技英才支持计划(NJYT24053) （NJYT24053）
中央引导地方科技发展资金项目(2023ZY0015) （2023ZY0015）
内蒙古自治区直属高校基本科研业务费(GXKY26Z068) （GXKY26Z068）
内蒙古自治区研究生教育教学改革项目(JG2025019Z) （JG2025019Z）
