法医学杂志2026，Vol.42Issue(3)：240-246,7.DOI:10.12116/j.issn.1004-5619.2026.360303
全自动磁性固相萃取仪在毒物、毒品检测中的应用
Application of Automatic Magnetic Solid-Phase Extraction Instrument in Toxic Substances and Illegal Drugs
摘要
Abstract
Magnetic solid-phase extraction(MSPE)serves as a key pretreatment technique for trace toxic substances and illegal drugs in complex matrices.Its degree of automation and extraction effi-ciency directly affect the sensitivity and reliability of analytical detection methods.At present,the de-tection of toxic substances and illegal drugs in forensic science continues to face challenges,including labor-intensive sample preparation,substantial matrix interference,limited enrichment efficiency,and dif-ficulty in controlling operational variability.Conventional solid-phase extraction(SPE)techniques largely rely on manual procedures and are therefore unable to simultaneously meet the requirements for high throughput,accuracy and repeatability in trace analyte analysis.To address these limitations,our team established a novel MSPE method with high enrichment factors based on a self-developed fully automated MSPE instrument(Model HS-401-1).Combined with fluorescence immunoassay,high-performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS),and gas chromato-graphy-mass spectrometry(GC-MS),the proposed method was applied to the sample pretreatment and quantitative analysis of toxic substances and illegal drugs in wastewater,blood and urine matrices.The results demonstrated that the extraction instrument could accelerate sample pretreatment,markedly increase enrichment factors,effectively reduce matrix interference,and enhance the response signals of target analytes.The accuracy and precision of the established method met the requirements for trace-level analysis.Practical forensic identification cases verified that the automated MSPE system was able to reduce human-induced operational errors and greatly improve the degree of automation and overall efficiency of the pretreatment workflow.This instrument provides a reliable technical solution for the screening of toxic substances and illicit drugs in forensic science and demonstrates significant academic value as well as promising prospects for widespread application.关键词
法医学/科技成果转化/全自动磁性固相萃取仪/毒物/毒品Key words
forensic medicine/technology transfer/automated magnetic solid-phase extraction instru-ment/toxic substances/illegal drugs分类
医药卫生引用本文复制引用
肖亚文,朱镜,张统书,王冰,张立妍,杨耀然,杨崇俊,孙艳,陈跃,韩乃寒,孟媛,王文君,任庆水..全自动磁性固相萃取仪在毒物、毒品检测中的应用[J].法医学杂志,2026,42(3):240-246,7.基金项目
刑事检验四川省高校重点实验室开放课题资助项目(2025YB03) （2025YB03）
山东警察学院人文社会科学计划资助项目(YKYPYZX202301,YKYPYZX202303) （YKYPYZX202301,YKYPYZX202303）
山东省自然科学基金资助项目(ZR2024QB327) （ZR2024QB327）
山东省高等学校青创科技支持计划资助项目(2022RW088,公安学科交叉融合创新团队) （2022RW088,公安学科交叉融合创新团队）
痕迹科学与技术公安部重点实验室开放课题资助项目(2022FMKFKT04) （2022FMKFKT04）
毒品分析及禁毒技术公安部重点实验室开放课题资助项目(ynpc2022kf002) （ynpc2022kf002）
