法医学杂志2026，Vol.42Issue(3)：254-260,7.DOI:10.12116/j.issn.1004-5619.2025.550604
三等位基因型案例的分类体系与PI计算方法实证
Empirical Classification of Tri-Allelic Genotype Cases and Parentage Index Calculation
摘要
Abstract
Objective To standardize the calculation method of the parentage index(PI)for short tan-dem repeat(STR)tri-allelic genotypes,thereby ensuring the accuracy and reliability of parentage tes-ting conclusions.Methods A systematic analysis of 160 real cases was conducted.A classification sys-tem was constructed based on the occurrence mechanisms and inheritance patterns of STR tri-alleles,and the PI calculation method was optimized by integrating previous research findings with empirical data.Results A mechanism-based classification system for STR tri-allelic genotypes was established,comprising Type I(2 subtypes),Type II(6 subtypes),and the trisomic type(2 subtypes).On this basis,a standardized PI calculation method covering all categories of STR tri-allelic genotypes was de-veloped.Conclusion This study provides methodological guidance for the scientific and standardized calculation of PI for STR tri-allelic genotypes and offers an important reference for the formulation and refinement of relevant industry standards.关键词
法医遗传学/短串联重复序列/三等位基因型/三体型/亲权指数Key words
forensic genetics/STR/tri-allelic pattern/trisomy/parentage index分类
医药卫生引用本文复制引用
杨乐,任贺,石妍,陈冲,贾莉,杨倩,刘雅诚,严江伟..三等位基因型案例的分类体系与PI计算方法实证[J].法医学杂志,2026,42(3):254-260,7.基金项目
国家自然科学基金重点项目(82030058) （82030058）
