甘肃医药2026，Vol.45Issue(5)：385-389,397,6.DOI:10.15975/j.cnki.1004-2725.2026.05.001
红景天苷调控多重信号网络保护糖尿病肾病的研究进展
Research progress on the protective effects of salidroside against diabetic kidney disease via regulating multiple signaling networks
摘要
Abstract
Diabetic kidney disease(DKD)stands as one of the most common causes of end-stage renal disease,with its global preva-lence continuously rising,while existing prevention and treatment strategies remain insufficient to meet clinical needs.Salidroside,the prima-ry active component of the traditional Chinese medicine Rhodiola rosea,has garnered attention for its broad pharmacological activities and potential therapeutic value for DKD.This article systematically reviews the research progress on the protective effects of salidroside against DKD.First,it outlines the epidemiological background and pathogenesis of DKD.Second,it summarizes the principal pharmacodynamic evi dence for salidroside in improving renal function indicators and alleviating renal pathological injuries(such as glomerulosclerosis and re-nal interstitial fibrosis).On this basis,it focuses on elucidating the synergistic protective mechanisms by which salidroside modulates a multi-faceted signaling network-including activation of the Nrf2-mediated antioxidant system,inhibition of NF-κB and MAPKs-mediated inflam-matory responses,and regulation of the JAK/STAT and mTOR pathways to attenuate fibrosis and protect podocyte function.Particular empha-sis is placed on the interplay and balance among these pathways in maintaining renal homeostasis.The conclusion indicates that salidroside exhibits therapeutic potential for DKD through a"multi-target synergistic regulation"signaling network.Future research should focus on con-ducting high-quality clinical trials,clarifying its pharmacokinetic properties,and optimizing dosing strategies to facilitate its clinical transla-tion and new drug development.关键词
红景天苷/糖尿病肾病/氧化应激/炎症反应/纤维化/信号通路Key words
Salidroside/diabetic kidney disease/ROS-mediated injury/inflammatory cascade/fibrotic lesion formation/signal trans-duction cascade分类
医药卫生引用本文复制引用
豆金彦,祁琴,李喜香,李红玉,安蓉芳,刘书斌..红景天苷调控多重信号网络保护糖尿病肾病的研究进展[J].甘肃医药,2026,45(5):385-389,397,6.基金项目
1.甘肃省自然科学基金项目(编号:23JRRA1246) （编号:23JRRA1246）
2.2025年中央财政医疗服务与保障能力提升(中医药事业传承与发展部分)——国家优势专科建设项目/全国名老中医药专家传承工作室建设项目(编号:甘财社[2024]118号) （中医药事业传承与发展部分）
