甘肃医药2026，Vol.45Issue(5)：390-397,8.DOI:10.15975/j.cnki.1004-2725.2026.05.002
乳腺癌中T细胞免疫反应的调控机制与治疗策略
Regulatory mechanisms and therapeutic strategies of T-Cell immune responses in breast cancer
摘要
Abstract
The efficacy of immunotherapy for breast cancer is limited by the highly heterogeneous tumor microenvironment(TME).T cells,as the core of adaptive immunity,dictate the outcome of immune responses through their functional state within the TME.This review sys-tematically describes the diversity of T cell functional subsets in the breast cancer TME and their clinical significance,and elucidates the multi-ple mechanisms that precisely regulate T cell function and fate.These mechanisms primarily include immune checkpoint signaling centered on the PD-1/PD-L1 and CTLA-4 axes,as well as nutrient competition and microenvironment acidification resulting from tumor cell metabolic re-programming(e.g.,the Warburg effect,tryptophan metabolism).Immune checkpoint inhibitors(ICIs)have become a standard treatment com-ponent for triple-negative breast cancer;adoptive cell therapies(e.g.,TILs,CAR-T)demonstrate the potential to overcome drug resistance;and combination therapies(e.g.,ICIs combined with radiotherapy,targeting CAFs,STING agonists)and emerging technologies(e.g.,radioligand ther-apy,nanodrug delivery systems)are becoming research hotspots.Future breakthroughs depend on a deeper understanding of the dynamics of the TME,developing precision treatment strategies targeting different immune phenotypes,and exploring effective biomarkers to achieve truly per-sonalized immunotherapy.关键词
乳腺癌/肿瘤微环境/T淋巴细胞/免疫检查点抑制剂/过继性细胞疗法/代谢重编程/联合治疗Key words
breast cancer/tumor microenvironment/T cells/immune checkpoint inhibitors/adoptive cell therapy/metabolic repro-gramming/combination therapy分类
医药卫生引用本文复制引用
李多龙,赵德贤,王玮,张瑞芳,严天鑫,李新月..乳腺癌中T细胞免疫反应的调控机制与治疗策略[J].甘肃医药,2026,45(5):390-397,8.基金项目
兰州市科技计划项目(编号:2024-9-74) （编号:2024-9-74）
