实用心电与临床诊疗2026，Vol.35Issue(4)：565-571,7.DOI:10.13308/j.issn.2097-5716.xd20250470
炎症细胞因子和抗氧化剂与冠状动脉粥样硬化的因果关系:双样本孟德尔随机化分析
Causal relationship of inflammatory cytokines and antioxidants with coronary atherosclerosis:a two-sample Mendelian randomization study
摘要
Abstract
Objective To systematically assess the causal relationship of circulating inflammatory cytokines and antioxidants with coronary atherosclerosis,aiming to overcome the limitations of confounding factors and reverse causation in traditional observational studies.Methods We performed a two-sample Mendelian randomization analysis using genetic instrumental variables for 27 inflammatory cytokines(n=8 293)and 4 antioxidants(n=86 995)from European cohorts.Data of coronary atherosclerosis were obtained from the FinnGen database(23 363 cases and 187 840 controls)and the UK Biobank(14 334 cases and 346 860 controls).The inverse-variance weighted method was used as primary analysis method,and multiple sensitivity analyses were conducted to assess the robustness of the results.Results In the Finnish cohort,genetically predicted higher C-reactive protein(CRP)levels significantly increased the risk of coronary atherosclerosis(OR=1.160,95%CI 1.095-1.228,P=4.60×10-7).TRAIL showed a positive association(OR=1.067,95%CI 1.031-1.103,P=1.96×10-4),whereas tumor necrosis factor-α(TNF-α;OR=0.917,95%CI 0.843-0.999,P=0.047)and α-tocopherol(OR=0.554,95%CI 0.344-0.890,P=0.015)exhibited protective effects.Validation in the UK Biobank cohort confirmed the findings for CRP(OR=1.007,95%CI 1.005-1.009,P=2.69×10-11),and revealed additional associations of TNF-β and RANTES with coronary atherosclerosis.No causal relationship was found between members of the interleukin family and coronary atherosclerosis.Conclusion This study provides genetic evidence for establishing the causal roles of specific inflammatory cytokines and antioxidants in the development of coronary atherosclerosis.Interventions targeting CRP and TRAIL,as well as increasing α-tocopherol levels,may offer novel strategies for early prevention of atherosclerotic disease.关键词
炎症/细胞因子/抗氧化物/冠状动脉粥样硬化/孟德尔随机化/因果效应/C反应蛋白/肿瘤坏死因子αKey words
inflammation/cytokine/antioxidant/coronary atherosclerosis/Mendelian randomization/causal effect/C-reactive protein/tumor necrosis factor-α分类
医药卫生引用本文复制引用
穆耶赛尔·麦麦提明,刘惠娟,王芳丽,印纹源,冯艳..炎症细胞因子和抗氧化剂与冠状动脉粥样硬化的因果关系:双样本孟德尔随机化分析[J].实用心电与临床诊疗,2026,35(4):565-571,7.基金项目
"天山英才"医药卫生高层次人才培养计划项目(TSYC202301A050) （TSYC202301A050）
新疆维吾尔自治区自然科学基金资助项目(2024D01C109) （2024D01C109）
