摘要
Abstract
Objective To investigate the influencing factors for prolonged corrected QT interval(QTc)on electrocardiogram(ECG)in long-term hospitalized patients with schizophrenia,and to construct a prediction model.Methods A total of 83 long-term hospitalized patients with schizophrenia were retrospectively enrolled as study subjects,all of whom received routine treatment.Patients were divided into a prolonged group(n=19)and a non-prolonged group(n=64)according to QTc value.General data and disease-related characteristics of all patients were collected.Factors influencing QTc prolongation in long-term hospitalized patients with schizophrenia were screened using LASSO regression and Logistic regression,and a nomogram prediction model was constructed;the predictive performance of the model was evaluated using ROC curve,calibration curve and decision curve analyses.Results There were statistically significant differences between the prolonged group and the non-prolonged group in age,sex,BMI,number of medication types,and serum potassium level(all P<0.05).Through LASSO regression analysis for non-zero coefficient feature selection,three characteristic variables—age,BMI,and number of medication types,were ultimately selected.Multivariate Logistic regression showed that age,BMI,and number of medication types were independent influencing factors for QTc prolongation in long-term hospitalized patients with schizophrenia(all P<0.05).ROC curve analysis results showed that the area under the curve for the combination of the above three indicators in predicting QTc prolongation was 0.877(95%CI 0.781-0.972),indicating good discriminative ability of the nomogram model.The Hosmer-Lemeshow test showed no significant deviation between the model-predicted probability and the actual probability(χ2=12.243,P>0.05),indicating good calibration of the model.Decision curve analysis results showed that the model yielded a higher net benefit for clinical prediction.Conclusion Factors influencing QTc prolongation on ECG in long-term hospitalized patients with schizophrenia include age,BMI,and number of medication types.The nomogram risk early-warning model constructed based on the above factors has certain predictive value for QTc prolongation in this population.关键词
精神分裂症/心电图/校正的QT间期/预测/体重指数Key words
schizophrenia/electrocardiogram/corrected QT interval/prediction/body mass index分类
医药卫生
