解放军医学院学报2026，Vol.47Issue(5)：441-446,462,7.DOI:10.12435/j.issn.2095-5227.26031301
NETosis在热射病发病机制与治疗策略中的研究进展
Research advances in NETosis in pathogenesis and treatment of heat stroke
摘要
Abstract
Heatstroke(HS)is a life-threatening condition characterized by central nervous system dysfunction and severe hyperthermia,which can rapidly progress to multiple organ dysfunction syndrome(MODS)and death.The pathogenesis of HS shares similarities with that of sepsis.NETosis,a unique form of neutrophil cell death,plays a central role in sepsis;however,its role in HS remains understudied and underappreciated.This review summarizes the current understanding of the role of NETosis in HS and HS-induced MODS.Furthermore,we discuss the scientific rationale and future prospects of targeting the NETosis pathway as a potential therapeutic strategy,with the goal of providing a theoretical foundation for elucidating the pathogenesis of HS and developing novel interventions.关键词
热射病/多器官功能障碍综合征/中性粒细胞炎性死亡/中性粒细胞胞外诱捕网Key words
heatstroke/multiple organ dysfunction syndrome/NETosis/neutrophil extracellular traps分类
医药卫生引用本文复制引用
胡婕,戴智,王黎,康红军,周飞虎..NETosis在热射病发病机制与治疗策略中的研究进展[J].解放军医学院学报,2026,47(5):441-446,462,7.基金项目
国家自然科学基金面上项目(82472238) （82472238）
省部级基金 （）
