临床与实验病理学杂志2026，Vol.42Issue(8)：1061-1067,7.DOI:10.13315/j.cnki.cjcep.2026.08.012
结直肠癌肿瘤与肿瘤微环境中的糖基化调控
Glycosylation-mediated regulation in colorectal cancer and its tumor microenvi-ronment
摘要
Abstract
Colorectal cancer(CRC)is a common malignancy worldwide.Patients with microsatellite stable(MSS)tumors generally respond poorly to immune checkpoint inhibitors(ICIs),largely because of an immunosuppres-sive tumor microenvironment(TME).As a major post-translational protein modification,glycosylation contributes to immune evasion in CRC by regulating the stability of immune checkpoint molecules and modulating immune cell acti-vation and functional reprogramming.This review discusses the immunoregulatory mechanisms of glycosylation repro-gramming in tumor,stromal,and immune cells within the TME,including truncated O-glycosylation,aberrant N-glycan branching,and hypersialylation.It also summarizes the biological functions of key glycosyltransferases and ex-amines the translational potential of glycosylation biomarkers for CRC diagnosis,prognostic assessment,and predic-tion of response to immunotherapy,providing a glycoimmunology perspective on precision treatment of CRC.关键词
结直肠肿瘤/肿瘤微环境/糖基化/免疫治疗/文献综述Key words
colorectal neoplasms/tumor microenvironment/glycosylation/immunotherapy/literature review分类
医药卫生引用本文复制引用
王艳茹,干文娟..结直肠癌肿瘤与肿瘤微环境中的糖基化调控[J].临床与实验病理学杂志,2026,42(8):1061-1067,7.基金项目
国家自然科学基金面上项目(82373142)、医疗卫生创新研究项目(CXYJ2024A09)、苏州工业园区卫生人才支持计划(YQWS202502) General Program of the National Natural Science Foundation of China(82373142) （82373142）
Medical and Health Innovation Research Project(CXYJ2024A09) （CXYJ2024A09）
Suzhou Industrial Park Health Talent Support Program(YQWS202502) （YQWS202502）
