环境与职业医学2026，Vol.43Issue(8)：917-925,9.DOI:10.11836/JEOM26038
孕期全氟及多氟烷基化合物暴露与胎儿脐带血中激素水平的关联
Association between prenatal exposure to per-and polyfluoroalkyl substances and hormone levels in fetal umbilical cord blood
摘要
Abstract
[Background]Per-and polyfluoroalkyl substances(PFAS)are synthetic chemicals characterized by environmental persistence and have been ubiquitously detected in pregnant women.Although existing evidence suggests that PFAS may exert endocrine-disrupting effects,evidence remains limited regarding the associations of individual legacy and emerging PFAS congeners,as well as PFAS mixtures,with fetal hormonal homeostasis. [Objective]Based on the Jiashan Birth Cohort in China,to investigate the associations between maternal plasma concentrations of legacy and emerging PFAS in the second trimester and levels of multiple hormones in fetal cord blood. [Methods]A total of 336 women in the second trimester from the Jiashan Birth Cohort were enrolled.Concentrations of 53 legacy and emerging PFAS were measured in maternal plasma,and levels of eight key hormones were de-termined in fetal cord blood.Multiple linear regression,restricted cubic spline,and Bayesian kernel machine regression models were used to examine the linear,nonlinear,and joint associations of individual PFAS and PFAS mixtures with fetal cord blood hormone levels. [Results]Maternal plasma concentrations of perfluorononanoic acid,perfluorohexane sulfonic acid,perfluorooctanesulfonic acid,and 8:2 chlorinated perfluoroether sulfonic acid were positively associated with cord blood levels of insulin-like growth factor 1(IGF1),with β values of 0.040,0.050,0.040,and 0.030,respectively(all P<0.05).In contrast,perfluoroheptanoic acid was negatively associated with prolactin levels(β=-0.060,P<0.01).Restricted cubic spline models revealed a nonlinear dose-response relationship between perfluo-robutane sulfonic acid and growth hormone(likelihood ratio test P=0.045),with a positive association in the intermediate concentration interval(β=0.261,P=0.010)that turned negative at higher concentrations(β=-0.425,P=0.048),as well as a nonlinear trend between 6:2 fluorotelomer sulfonic acid and prolactin(likelihood ratio test P=0.074).Bayesian kernel machine regression analysis indicated a negative trend between PFAS mixture exposure and cord blood prolactin levels. [Conclusion]Maternal PFAS exposure in the second trimester is associated with higher insulin-like growth factor 1 levels and lower prolactin levels in fetal cord blood.Prolactin appears to be consistently associated with both individual PFAS congeners and PFAS mixtures.These findings suggest that maternal PFAS exposure may affect fetal endocrine homeostasis by disrupting the hypothalamic-pituitary-prolactin regulatory axis.关键词
全氟及多氟烷基化合物/产前暴露/内分泌干扰/混合暴露/胎儿脐带血激素Key words
per-and polyfluoroalkyl substance/prenatal exposure/endocrine disruption/mixed exposure/fetal umbilical cord blood hor-mone分类
医药卫生引用本文复制引用
孙康奡,伍燕梅,傅红冰,王霞,梁红,薛靖川..孕期全氟及多氟烷基化合物暴露与胎儿脐带血中激素水平的关联[J].环境与职业医学,2026,43(8):917-925,9.基金项目
国家自然科学基金基础科学中心项目(52388101) （52388101）
