皮肤性病诊疗学杂志2026，Vol.33Issue(8)：606-614,9.DOI:10.3969/j.issn.1674-8468.2026.08.008
离子通道在银屑病发病机制中的作用
Role of ion channels in the pathogenesis of psoriasis
摘要
Abstract
Psoriasis is a chronic inflammatory disease involving immune dysregulation,abnor-mal proliferation of keratinocytes(KCs),and neurogenic inflammation,with its molecular mecha-nisms not yet fully elucidated.Ion channels,as core components of cellular signal transduction,play a pivotal regulatory role in these pathological processes.This article systematically summari-zes recent advances in the roles of transient receptor potential(TRP)channels,potassium chan-nels,calcium channels,purinergic P2X receptors(P2XR),and mechanosensitive Piezo channels in the dysfunction of KCs,immune-mediated inflammation,and neuro-immune-skin interactions in psoriasis.For the first time,it proposes a"Ca2+signaling pathway network-chronic inflammation loop-neural sensitization"cascade amplification integration model,illustrating how different types of ion channels synergistically drive disease progression within the psoriatic microenvironment.Ad-ditionally,this review summarizes advances in the clinical translation of ion channel-targeted ther-apies,with a focus on the development status and challenges of candidate agents such as Kv 1.3 inhibitors,calcium release-activated calcium(CRAC)channel antagonists,and TRPV channel modulators,aiming to provide new insights for precision-targeted treatment of psoriasis.关键词
银屑病/离子通道/瞬时受体电位离子通道/免疫炎症/角质形成细胞/神经源性炎症Key words
psoriasis/ion channels/transient receptor potential channels/immune-medi-ated inflammation/keratinocytes/neurogenic inflammation引用本文复制引用
汤自洁,李承新,王睿..离子通道在银屑病发病机制中的作用[J].皮肤性病诊疗学杂志,2026,33(8):606-614,9.基金项目
国家自然科学基金(82504266 （）
82273530) （）
