皮肤性病诊疗学杂志2026，Vol.33Issue(8)：628-632,5.DOI:10.3969/j.issn.1674-8468.2026.08.011
硼中子俘获疗法治疗皮肤恶性肿瘤的研究进展
Advances in boron neutron capture therapy for cutaneous malignancies
黄翠儿 1刘文琪 1李常兴1
作者信息
- 1. 南方医科大学第十附属医院(东莞市人民医院),广东 东莞 523000
- 折叠
摘要
Abstract
As an effective therapeutic strategy for malignant neoplasms,boron neutron capture therapy(BNCT)has demonstrated promising clinical outcomes across various cutaneous malignan-cies.Multicenter studies in melanoma have reported complete response rates of 73%-78%,an overall disease control rate of 88%,and a 5-year disease-specific survival of 58%,with managea-ble toxicities including cutaneous radiation injury.For genital melanoma and extramammary Paget disease,BNCT has shown promising efficacy.In the first-in-human phase Ⅰ trial for cutaneous angiosarcoma,BNCT achieved a best overall response rate of 70%and a 2-year overall survival rate of 90.0%.Additionally,BNCT has exhibited therapeutic potential in cutaneous metastases and soft tissue sarcomas with cutaneous or subcutaneous involvement.This review systematically summarizes clinical advances in BNCT for cutaneous malignancies and discusses its clinical feasi-bility,current limitations,and future prospects.关键词
硼中子俘获疗法/硼中子载体/皮肤恶性肿瘤Key words
boron neutron capture therapy/boron delivery agents/cutaneous malignancies引用本文复制引用
黄翠儿,刘文琪,李常兴..硼中子俘获疗法治疗皮肤恶性肿瘤的研究进展[J].皮肤性病诊疗学杂志,2026,33(8):628-632,5.
