老年医学与保健2026，Vol.32Issue(4)：545-550,6.DOI:10.3969/j.issn.1008-8296.2026.04.013
红细胞分布宽度与白蛋白比值、同型半胱氨酸、C反应蛋白与老年共病患者继发衰弱的相关性
Correlation between red blood cell distribution width/albumin ratio,homocysteine,C-reactive protein and secondary frailty in older patients with comorbidities
摘要
Abstract
Objective To explore the correlation between red blood cell distribution width(RDW)/albumin(ALB),homocysteine(Hcy),C reactive protein(CRP)and secondary frailty after comprehensive intervention for sarcopenia in older patients with comorbidities,and evaluatethe predictive value of their combined application for secondary frailty after comprehensive intervention.Methods A total of 120 older patients with comorbidities and sarcopenia admitted to the Second People's Hospital of Kunming from January 2024 to May 2025 were prospectively selected.Based on the occurrence of secondary frailty after comprehensive intervention,they were divided into frail group(34 cases)and non-frail group(86 cases).The baseline data of the two groups were compared.The propensity score matching was applied to reduce intergroup bias.The levels of RDW/ALB,Hcy and CRP were compared between the two groups.The effects of these indicators on secondary frailty in older patients with comorbidities after comprehensive intervention for sarcopenia was analyzed,and their individual and combined predictive values for secondary frailty in older patients with comorbidities after comprehensive intervention for sarcopenia was analyzed.Results The levels of RDW/ALB,Hcy and CRP in the frail group were higher than those in the non-frail group(P＜0.05).Elevated levels of RDW/ALB,Hcy and CRP were independently associated with secondary frailty after comprehensive intervention for sarcopenia in older patients with comorbidities(P＜0.05).In individual prediction,RDW/ALB showed the largest area under the curve(AUC),CRP had the highest sensitivity,and Hcy demonstrated the highest specificity(P＜0.05).The combined prediction AUC value of CRP+RDW/ALB+Hcy was significantly higher than that of each individual indicator.Conclusion RDW/ALB,Hcy and CRP are associated with the development of secondary frailty after comprehensive intervention for sarcopenia in older patients with comorbidities.Their combined detectioncan provide a valuable reference for the clinical prediction of secondary frailty.关键词
老年人/共病/肌少症/衰弱/红细胞分布宽度与白蛋白比值/同型半胱氨酸/C反应蛋白Key words
older adults/comorbidity/sarcopenia/frailty/red cell volume distribution width/albumin ratio/homocysteine/C-reactive protein引用本文复制引用
李海欣,马继娟,吴红宝,梁碧娟,苏建培,顾俊,王志敏,李瑞乾,陈玉兰,杨磊,闻丽芬,代林玲..红细胞分布宽度与白蛋白比值、同型半胱氨酸、C反应蛋白与老年共病患者继发衰弱的相关性[J].老年医学与保健,2026,32(4):545-550,6.基金项目
昆明市科技计划项目(2024-1-NS-029,2025-NS-018) （2024-1-NS-029,2025-NS-018）
昆明市卫生科技人才培养项目医学科技学科带头人培养计划[2025-SW(带头)-38] （带头）
昆明市卫生健康委员会卫生科研课题项目(2025-03-10-001) （2025-03-10-001）
