生物医学工程研究2026，Vol.45Issue(4)：311-318,8.DOI:10.19529/j.cnki.1672-6278.2026.04.07
基于多物理场耦合的脉冲电场消融房颤的数值研究
Numerical study of atrial fibrillation ablation with pulsed electric fields based on multiphysics coupling
摘要
Abstract
To investigate the distribution of electric field intensity at different depths(0.5～4.5 mm)from the myocardial surface during pulsed field ablation(PFA)for atrial fibrillation,as well as the impact of different voltages(500～2000 V)on the ablation re-gion,we established a multiphysics-coupled PFA heart model based on COMSOL Multiphysics 6.1.The results showed that there exis-ted a coupled mechanism of electric field-conductivity-temperature in the ablation process,under 500 V pulse voltage,the maxi-mum temperature within the myocardium was 41.18 ℃,always below the myocardial thermal injury threshold of 50 ℃.In the 0～2.5 mm region of the myocardial surface,the electric field intensity was as high as 1000 V/cm,reaching the threshold of 400 V/cm re-quired for irreversible electroporation(IRE)of the myocardium,whereas the region with a depth greater than 3.5 mm had an electric field intensity of approximately 350 V/cm,insufficient for effective ablation.When the voltage increased from 500 to 2000 V,the in-creased in ablation depth,width and injury volume were 86.21％,43.37％and 412.16％,respectively.This study explores the action mechanism and non-thermal dominant characteristics of pulsed electric field parameters on the myocardium,and the revealed mul-tiphysics coupling rules can provide theoretical support for optimizing ablation parameters.关键词
脉冲电场消融/多物理场耦合/心肌组织/电场/电导率/温度Key words
Pulsed field ablation/Multiphysics coupling/Myocardial tissue/Electric field/Conductivity/Temperature分类
医药卫生引用本文复制引用
赵晓玲,翁旭东,南群..基于多物理场耦合的脉冲电场消融房颤的数值研究[J].生物医学工程研究,2026,45(4):311-318,8.基金项目
北京市自然科学基金项目(QY25371). （QY25371）
