天津中医药大学学报2026，Vol.45Issue(8)：994-1000,7.DOI:10.11656/j.issn.1673-9043.2026.08.14
针灸治疗炎症性肠病的自主神经调节机制研究进展
Research progress on the autonomic neuromodulation mechanisms of acupuncture in treating inflammatory bowel disease
摘要
Abstract
The incidence of inflammatory bowel disease(IBD)has been rising annually,closely linked to autonomic nervous system dysfunction.In traditional Chinese medicine,IBD falls into categories such as"dysentery"and"diarrhea",with its pathogenesis rooted in spleen deficiency and damp-heat accumulation in the intestine.Acupuncture treats IBD by regulating autonomic function.Electroacupuncture at Zusanli(ST36)inhibits sympathetic-sensory coupling and elevates norepinephrine levels to reduce inflammation.Simultaneously,it activates the vagus nerve and its cholinergic anti-inflammatory pathway,suppressing inflammatory cytokine secretion and repairing the intestinal barrier.Acupoint selection is primarily based on the Stomach Meridian of Foot-Yangming,combined with local and distal points,embodying the holistic regulatory concept of TCM.Additionally,acupuncture modulates immune cell balance(such as the Th17/Treg ratio)and promotes mucosal repair,exerting multi-target,bidirectional regulatory effects.This review systematically summarizes the autonomic mechanisms of acupuncture in IBD treatment,providing scientific evidence for its clinical application.关键词
炎症性肠病/针刺治疗/自主神经/免疫调节Key words
inflammatory bowel disease/acupuncture/autonomic nervous system/immune regulation分类
医药卫生引用本文复制引用
李雪,赵一宁,李飞洋,杨元祯,王佳琦,公一囡,徐枝芳..针灸治疗炎症性肠病的自主神经调节机制研究进展[J].天津中医药大学学报,2026,45(8):994-1000,7.基金项目
国家自然科学基金青年基金项目(8220153296) （8220153296）
国家重点研发计划课题项目(2022YFC3500404) （2022YFC3500404）
天津市科技计划项目(22JCZXJC00070). （22JCZXJC00070）
