武警医学2026，Vol.37Issue(8)：664-668,5.DOI:10.3969/j.issn.1004-3594.2026.08.003
8岁前后儿童肺炎支原体肺炎临床特征及治疗策略
Clinical features and treatment strategies of mycoplasma pneumoniae pneumonia in chil-dren around the age of 8
摘要
Abstract
Objective To analyze the differences in clinical features,etiological distribution and treatment strategies of myco-plasma pneumoniae pneumonia(MPP)in children around the age of 8,so as to provide evidence for age-stratified individualized diag-nosis and treatment.Methods A retrospective analysis was conducted on the data of 167 hospitalized children with MPP diagnosed by targeted next-generation sequencing(tNGS)in the pediatric department of Beijing Haidian Hospital from November 2023 to April 2024.The patients were divided into the<8-year-old group(n=71)and the≥8-year-old group(n=96).The two groups were com-pared in terms of clinical manifestations,laboratory parameters,etiological features and treatment strategies.Results The detection rate of macrolide-resistant MPP exceeded 88%,and there was no statistically significant difference between the groups(P=0.702).The incidence of refractory MPP was 39.4%in the group aged<8 years,which was higher than 20.8%in the group aged≥8 years,and the difference was statistically significant(P=0.014).The co-infection rate of viruses was 26.7%in the<8-year-old group,also higher than 14.6%in the≥8-year-old group,with statistically significant difference(P=0.003).The levels of C-reactive protein and D-dimer were significantly higher in the≥8-year-old group than in the<8-year-old group(P<0.05),and the difference was statisti-cally significant(P<0.05),while the level of lactate dehydrogenase was higher in the<8-year-old group than that in the≥8-year-old group,and the difference was statistically significant(P=0.009).The utilization rate of doxycycline/minocycline was 79.2%in the≥8-year-old group,notably higher than 33.8%in the<8-year-old group,and the difference was statistically significant(P<0.001).Conclusions During the 2023-2024 epidemic period,childhood MPP is characterized by a high rate of macrolide resistance,with no significant difference among age groups.Children under 8 years are more likely to have a refractory course and viral co-infections,high-lighting the need for enhanced early detection.Children aged 8 and above have a more severe inflammatory responses,requiring intensified anticoagulation monitoring.关键词
肺炎支原体肺炎/大环内酯类耐药/呼吸道多种病原体靶向测序/难治性肺炎/年龄差异Key words
mycoplasma pneumoniae pneumonia/macrolide resistance/targeted sequencing of multiple respiratory pathogens/re-fractory pneumonia/age difference分类
医药卫生引用本文复制引用
孟淑萍,于丽娟,魏晓琼,王媛媛,常艳美..8岁前后儿童肺炎支原体肺炎临床特征及治疗策略[J].武警医学,2026,37(8):664-668,5.基金项目
北京市海淀医院科研基金项目(KYQ2022017) （KYQ2022017）
