应用化学2026，Vol.43Issue(8)：1185-1203,19.DOI:10.19894/j.issn.1000-0518.260251
金属基纳米材料在卵巢癌诊疗中的研究进展
Research Progress of Metal-Based Nanomaterials in Theranostics of Ovarian Cancer
摘要
Abstract
Ovarian cancer is the most lethal malignant tumor of the female reproductive system.This disease has insidious early symptoms and lacks effective screening methods,so most patients are diagnosed at advanced stages,resulting in a high recurrence rate after surgery and an extremely poor overall prognosis.Benefiting from their favorable properties including excellent biocompatibility,tunable surface functionalization,and multimodal imaging capacity,metal-based nanomaterials exhibit tremendous application potential in the early diagnosis,precise treatment,and therapeutic response surveillance of ovarian cancer.This review systematically categorizes and characterizes various metal-based nanomaterials,elaborates on their core mechanisms underlying tumor microenvironment responsiveness,antitumor biological effects,multimodal imaging signal amplification,and synergistic theranostic integration,and comprehensively discusses their research progress across the full-cycle clinical management of ovarian cancer,including early screening,preoperative precise imaging,intraoperative navigation resection,and postoperative dynamic monitoring.Collectively,this work delivers innovative strategies for the diagnosis and treatment of ovarian cancer.Meanwhile,this paper conducts hierarchical analysis targeting the core pathological challenge of characteristic extensive peritoneal dissemination in ovarian cancer,and constructs a systematic sorting framework centered on clinical diagnosis and treatment demands.关键词
金属基纳米材料/卵巢癌/诊断/治疗/诊疗一体化纳米平台Key words
Metal-based nanomaterials/Ovarian cancer/Diagnosis/Therapy/Theranostic nanoplatform分类
化学化工引用本文复制引用
高思宇,刘思文,吕俊锋..金属基纳米材料在卵巢癌诊疗中的研究进展[J].应用化学,2026,43(8):1185-1203,19.基金项目
吉林省科技发展项目(No.20260203148SF)资助 Supported by the Science and Technology Development Project of Jilin Province(No.20260203148SF) （No.20260203148SF）
