中草药2026，Vol.57Issue(17)：6669-6676,8.DOI:10.7501/j.issn.0253-2670.2026.17.002
斜叶黄檀中1个新的异黄酮类化合物
A new isoflavone compound isolated from Dalbergia pinnata
摘要
Abstract
Objective To investigate the chemical composition of the rhizome of Dalbergia pinnata.Methods Separation and purification were performed using silica gel,RP-C18,MCI,Sephadex LH-20 column chromatography,semi-preparative high-performance liquid chromatography and recrystallization;compound structures were identified based on spectroscopic techniques,including NMR spectroscopy;and the anti-complement activity of selected isolated monomeric compounds was screened using an in vitro erythrocyte hemolysis assay.Results Fifteen compounds were isolated and identified from the ethyl acetate fraction of D.pinnata,including 5,7,4'-trihydroxy-6,2',5'-trimethoxyisoflavone(1),7,3'-dihydroxy-8,4'-dimethoxyisoflavone(2),(-)-vestitol(3),3-O-acetyloleanolic acid(4),(-)-hydroxymedioresinol(5),(-)-episyringaresinol(6),(-)-liquiritigenin(7),butein(8),(-)-isolariciresinol(9),(+)-lyoniresinol(10),(2R)-3-(3',4'-dimethoxyphenyl)-1,2-propanediol(11),(2R)-3-(3',4',5'-trimethoxyphenyl)-1,2-propanediol(12),3,3',4,4'-tetrahydroxybiphenyl(13),vanillicvanillyric acid(14),cinnamtannin B1(15).In vitro anti-complement activity assays demonstrated that compounds 1,3,7 and 8 exhibited distinct in vitro complement inhibitory activities,with their half-maximal hemolysis-inhibitory concentrations(CHs0)measuring(1.21±0.07),(0.57±0.03),(0.12±0.13)and(0.17±0.04)mg/mL respectively.Conclusion Compound 1 is a new compound,designated as dalbergiaisoflavone A,obtained from D.pinnata;compounds 2-6 and 8-15 were obtained from this species for the first time,and compound 7 exhibits significant in vitro anti-complement activity.关键词
斜叶黄檀/斜叶异黄酮A/7,3'-二羟基-8,4'-二甲氧基异黄酮/(-)-甘草素/(-)-异落叶松脂素/抗补体活性Key words
Dalbergia pinnata(Lour.)Prain/dalbergiaisoflavone A/3',7-dihydroxy-8,4'-dimethoxyisoflavone/(-)-liquiritigenin/(-)-isolariciresinol/anti-complement activity分类
医药卫生引用本文复制引用
熊亚兰,朱敏,廖土花,卢澄生,黄嫊琳,王广贤,韦建华,梁臣艳,冯旭..斜叶黄檀中1个新的异黄酮类化合物[J].中草药,2026,57(17):6669-6676,8.基金项目
广西自然科学基金项目(2024GXNSFAA010266) （2024GXNSFAA010266）
广西自然科学基金项目(2024GXNSFAA010326) （2024GXNSFAA010326）
广西特色中药现代化产业学院2024年大学生创新创业训练计划立项项目(C202409) （C202409）
广西中医药大学自然科学基金项目(2022MS031) （2022MS031）
