中草药2026，Vol.57Issue(17)：6677-6681,5.DOI:10.7501/j.issn.0253-2670.2026.17.003
柚木中2个新的萘醌及其抗真菌活性
Two new naphthoquinones from leaves of Tectona grandis and their antifungal activity
摘要
Abstract
Objective To investigate the chemical constituents of the leaves of Tectona grandis,and search for antifungal active ingredients.Methods The compounds were obtained by silica gel,MCI,and prep-HPLC column chromatography.Their structures were identified by HRESIMS,IR,1D-and 2D NMR analysis.The isolates were tested for their antifungal activity by 96 well plate microbroth dilution method.Results Two new naphthoquinones,(E)-2,5,8-trihydroxy-3-(4-acetoxy-3-methylbut-2-en-1-yl)-1,4-naphthoquinone(1)and(E)-2,5,8-trihydroxy-3-(4-hydroxy-3-methylbut-2-en-1-yl)-1,4-naphthoquinone(2),were isolated from the 90％MeOH extract of the leaves of T.grandis.Compounds 1 and 2 exhibited significant antifungal activity when combined with fluconazole,against fluconazole-resistant Candida albicans with MIC5o values of 3.28 and 5.32 μg/mL,respectively.Conclusion Compounds 1 and 2,named tectonagrandiones A and B,were two new naphthoquinones,and the naphthoquinones might be the active antifungal constituents from T.grandis.关键词
柚木/马鞭草科/萘醌/抗真菌活性/柚木萘醌A/柚木萘醌BKey words
Tectona grandis L./Verbenaceae/naphthoquinones/antifungal activity/tectonagrandiones A/tectonagrandiones B分类
医药卫生引用本文复制引用
黄春球,的日克拉,全咏洁,杜文豪,杨野,左爱学,肖艳,江志勇..柚木中2个新的萘醌及其抗真菌活性[J].中草药,2026,57(17):6677-6681,5.基金项目
国家自然科学基金项目(82360688) （82360688）
云南省中医药联合专项重点项目(202101AZ070001-164) （202101AZ070001-164）
云南省教育厅高原特色民族药用植物研究科技创新团队 （）
国家中医药管理局高水平中医药重点学科建设项目-傣药学(Zyyzdxk-2023192) （Zyyzdxk-2023192）
