中风与神经疾病杂志2026，Vol.43Issue(8)：686-691,6.DOI:10.19845/j.cnki.zfysjjbzz.2026.0119
前庭性偏头痛相关认知功能障碍的研究进展
Research advances in cognitive impairment associated with vestibular migraine
摘要
Abstract
Vestibular migraine(VM)is not only a common cause of episodic vertigo but also a systemic disorder in-volving extensive brain network dysfunction.In addition to typical headache and severe vestibular symptoms,VM is often accompanied by significant cognitive alterations that seriously impair the daily functioning and social capacity of patients.This article systematically reviews the latest research advances in VM-associated cognitive impairment in terms of clinical phenotypes,potential pathophysiological mechanisms,biomarkers,and assessment scales.Clinical assessments show that VM-associated cognitive impairment mainly manifests as retardation of thinking,impaired attention and working memory,increased cognitive load,and impaired executive function,as well as a potential increase in the risk of falls.Neuroimaging and neuroelectrophysiological evidence has revealed the presence of microstructural damage along with mac-roscopic functional network reorganization and structural alterations in the brains of VM patients.Besides,5-hydroxytryp-tamine,calcitonin gene-related peptide,macrophage migration inhibitory factor,and 25-OH vitamin D may participate in the development and progression of VM-associated cognitive impairment.In conclusion,through a comprehensive assess-ment of scales,neuroimaging,electrophysiological examination,and serological biomarkers,cognitive screening in VM patients can achieve early detection of cognitive dysfunction,and effective interventions should be performed to control the symptoms of VM while protecting cognitive function,so as to improve long-term prognosis and quality of life for these pa-tients.关键词
前庭性偏头痛/认知功能障碍/脑网络异常/生物学标志物Key words
Vestibular migraine/Cognitive impairment/Brain network abnormalities/Biomarkers分类
医药卫生引用本文复制引用
漆微玮,廖松洁..前庭性偏头痛相关认知功能障碍的研究进展[J].中风与神经疾病杂志,2026,43(8):686-691,6.基金项目
医院临床专科能力建设支持计划高水平临床研究专项(R70076) （R70076）
广东省神经系统疾病临床医学研究中心(2020B1111170002) （2020B1111170002）
广东省神经疾病早期干预及功能修复研究国际科技合作基地(2020A0505020004) （2020A0505020004）
广州市重大疑难(罕见)疾病项目——肌无力诊疗中心(2024MDRD02) （罕见）
