中风与神经疾病杂志2026，Vol.43Issue(8)：696-699,4.DOI:10.19845/j.cnki.zfysjjbzz.2026.0121
降钙素基因相关肽在丛集性头痛发病机制及鉴别诊断中的研究进展
Research progress of calcitonin gene-related peptide in the pathogenesis and differential diagnosis of cluster headache
摘要
Abstract
Cluster headache(CH)is a severe primary headache disorder characterized by excruciating pain,with a complex pathophysiology involving intricate interactions among the trigeminovascular system,the hypothalamic circadian clock,and the autonomic nervous system.In recent years,calcitonin gene-related peptide(CGRP),recognized as a core mediator in migraine pathophysiology,has also attracted substantial attention regarding its role in CH.This review aims to thoroughly dissect the central role of CGRP in the pathogenesis of CH,systematically elaborate on the relationship between the circadian rhythmicity of CH attacks and the regulation of CGRP pathways,and,through differential diagnostic analysis of CH versus other trigeminal autonomic cephalalgias,reveal the distinct roles of CGRP pathways across different head-ache subtypes.By integrating the latest preclinical studies,clinical trial data,and biomarker explorations,this article seeks to provide a comprehensive reference for understanding the complex pathophysiology of CH and for developing novel targeted therapeutic strategies.关键词
丛集性头痛/降钙素基因相关肽/阵发性偏侧头痛/伴结膜充血和流泪的短暂单侧神经痛样头痛发作/持续性偏侧头痛Key words
Cluster headache/Calcitonin gene-related peptide/Paroxysmal hemicrania/Short-lasting uni-lateral neuralgiform headache attacks with conjunctival injection and tearing/Hemicrania continua分类
医药卫生引用本文复制引用
许英,董天一,巩宇虹,陈俊玮,李一凡,于澎,董铭..降钙素基因相关肽在丛集性头痛发病机制及鉴别诊断中的研究进展[J].中风与神经疾病杂志,2026,43(8):696-699,4.基金项目
吉林省卫生健康科技能力提升项目(2024A015) （2024A015）
