中风与神经疾病杂志2026，Vol.43Issue(8)：700-703,4.DOI:10.19845/j.cnki.zfysjjbzz.2026.0122
偏头痛合并颞下颌关节紊乱的共病机制及临床诊疗意义
Comorbid mechanisms of migraine and temporomandibular disorders and their clinical diagnostic and therapeutic significance
摘要
Abstract
Migraine is a common primary headache disorder with a high disability burden,and temporomandibular disorders(TMD)are among the most prevalent chronic pain conditions in the orofacial region.Studies have shown a sig-nificant bidirectional comorbidity between migraine and TMD,with pain-related TMD being particularly closely associated with migraine.Patients with this comorbidity often experience greater pain burden,more pronounced psychological dis-tress,and poorer quality of life.The underlying mechanisms may involve multiple factors,including the convergence of pain signals within the trigeminal system,peripheral and central sensitization,abnormal neuropeptide signaling involving calcitonin gene-related peptide,oral parafunctional behaviors,sleep disturbances,and psychological stress.The third edition of the International Classification of Headache Disorders(ICHD-3)classifies"headache attributed to temporoman-dibular disorder"as an entry for secondary headache diagnosis.Clinically,attention should be paid to differentiating mi-graine comorbid with TMD from TMD-related secondary headache.This review focuses on the epidemiological association,potential comorbid mechanisms,diagnostic differentiation,and oral clinical implications of migraine and TMD,aiming to provide a reference for the standardized identification and comprehensive management of affected patients.关键词
偏头痛/颞下颌关节紊乱/中枢敏化/共病Key words
Migraine/Temporomandibular disorders/Central sensitization/Comorbidity分类
医药卫生引用本文复制引用
闫弘静,鞠昊,冯婧,蔡研,董铭..偏头痛合并颞下颌关节紊乱的共病机制及临床诊疗意义[J].中风与神经疾病杂志,2026,43(8):700-703,4.基金项目
吉林省卫生健康科技能力提升项目(2024A015) （2024A015）
