中国肺癌杂志2026，Vol.29Issue(7)：548-556,9.DOI:10.3779/j.issn.1009-3419.2026.102.21
非小细胞肺癌脑转移中肿瘤细胞与脑微环境互作机制研究进展
Tumor Cell and Brain Microenvironment Interactions in Non-small Cell Lung Cancer Brain Metastasis:Mechanisms and Emerging Insights
杨贺淇 1周清华1
作者信息
- 1. 610041 成都,四川大学华西医院肺癌研究所/肺癌中心
- 折叠
摘要
Abstract
Brain metastasis in non-small cell lung cancer(NSCLC)is shaped by continuous interactions between tumor cells and the brain-specific microenvironment.Vascular,glial and immune components contribute to intracranial colo-nization,immune escape and therapeutic resistance,while single-cell and spatial omics reveal heterogeneity in cellular states,communication networks and spatial niches.This review summarizes NSCLC brain metastasis and intracranial colonization,the brain metastatic microenvironment and tumor-microenvironment interactions,and discusses the heterogeneity revealed by single-cell and spatial omics and its potential relevance to therapeutic response and patient stratification.关键词
肺肿瘤/脑转移/肿瘤微环境/单细胞测序/空间组学Key words
Lung neoplasms/Brain metastasis/Tumor microenvironment/Single-cell sequencing/Spatial omics引用本文复制引用
杨贺淇,周清华..非小细胞肺癌脑转移中肿瘤细胞与脑微环境互作机制研究进展[J].中国肺癌杂志,2026,29(7):548-556,9.
