中国药理学与毒理学杂志2026，Vol.40Issue(7)：547-558,12.DOI:10.3867/j.issn.1000-3002.2026.08888
《中华人民共和国药典》2025版有毒中药肾毒性机制与减毒策略研究进展
Progress in research on mechanisms of nephrotoxicity and detoxi-fication strategies for toxic traditional Chinese medicines in the 2025 edition of the Pharmacopoeia of the People's Republic of China
摘要
Abstract
Toxic Chinese herbal medicines play a role in treating diseases by"attacking pathogenic factors and repeatedly curing intractable ailments using poison".However,their clinical applications are limited by toxicities of these medicines,such as hepatotoxicity,nephrotoxicity and cardiotoxicity.Based on the classification of toxic Chinese herbal medicines stipulated in the 2025 edition of the Pharmaco-poeia of the People's Republic of China,this paper begins by demonstrating the central role of dosage and syndrome differentiation in the manifestation of drug toxicity.The mechanisms of nephrotoxicity of toxic Chinese herbal medicines and methods for reducing toxicity are explored.Four common toxic pathways associated with drug-induced nephrotoxicity are summarized:oxidative stress damage,acti-vation of inflammatory pathways,disruption of metabolic pathways,and apoptosis.Based on mechanistic research,the paper expands the toxicity-reducing strategy from the traditional two-dimensional frame-work of"processing and formulation"to a four-dimensional system comprising"processing,formulation,syndrome differentiation and dosage"in the hope of providing a reference for safe and rational clinical applications of toxic Chinese herbal medicines,as well as for enhancing their efficacy while reducing toxicity.关键词
《中华人民共和国药典》/有毒中药/肾毒性/量效关系/炮制减毒/辨证论治Key words
Pharmacopoeia of the People's Republic of China/toxic Chinese herbal medicines/nephrotoxicity/dose-effect relationship/detoxification by processing/treatment based on syndrome differentiation分类
医药卫生引用本文复制引用
赵文龙,程睿涵,张晨霜,李宝龙..《中华人民共和国药典》2025版有毒中药肾毒性机制与减毒策略研究进展[J].中国药理学与毒理学杂志,2026,40(7):547-558,12.基金项目
国家自然科学基金项目(81573135) （81573135）
黑龙江省自然科学基金项目(LH2023H056) （LH2023H056）
黑龙江省博士后科研启动项目(LBH-Q21042) National Natural Science Foundation of China(81573135) （LBH-Q21042）
Natural Science Foundation of Heilongjiang Province(LH2023H056) （LH2023H056）
and Heilongjiang Postdoctoral Science Foundation Initiation Grant(LBH-Q21042) （LBH-Q21042）
