中国医学创新2026，Vol.23Issue(24)：17-21,5.DOI:10.3969/j.issn.1674-4985.2026.24.005
地塞米松与泼尼松诱导缓解治疗中高危ALL患儿的效果比较
Comparison on the Efficacy of Remission Induction with Dexamethasone and Prednisone in Children with Moderately and High-risk ALL
摘要
Abstract
Objective:To compare the efficacy of remission induction with Dexamethasone and Prednisone in children with moderately high-risk acute lymphoblastic leukaemia(ALL).Method:A total of 120 children with moderately high-risk ALL admitted to Jiangxi Provincial Children's Hospital were enrolled from June 2021 to June 2023.According to random number table method,they were divided into control group and study group,60 cases in each group.In treatment window phase,all children were given oral Dexamethasone from 1st-4th day after treatment,control group was given PVDL regimen(Prednisone+Vincristine+Daunorubicin+L-asparaginasum)during remission induction,the study group replaced Prednisone with Dexamethasone in the control group protocol,while the rest remained the same as the control group.The 2-year event-free survival(EFS)rate,overall survival(OS)rate,treatment effectiveness and safety were compared between the two groups.Result:As of the last follow-up,there were 2 cases giving up and 5 cases with recurrence or death in study group,while there were 3 cases transferred or giving up,14 cases with recurrence or death in control group.The 2-year OS rate 88.3%[95%CI(80.1%,96.5%)]and 2-year EFS rate 78.3%[95%CI(67.9%,88.7%)]in study group were higher than 70.7%[95%CI(58.5%,82.9%)],58.3%[95%CI(45.8%,70.8%)]in control group(P<0.05).The complete remission rate in study group(88.33%)was higher than that in control group(73.33%)(P<0.05).There was no significant difference in negative rate of minimal residual disease(MRD)on the 19th day between study group(51.67%)and control group(43.33%)(P>0.05),but negative rate of MRD on the 46th day in study group(89.47%)was higher than that in control group(72.41%)(P<0.05).There was no significant difference in treatment safety between the two groups(P>0.05).Conclusion:Compared with Prednisone,8 mg/(m2·d)Dexamethasone can significantly increase 2-year EFS rate and OS rate,and will not increase obvious side effects,and demonstrates good therapeutic efficacy and safety.关键词
急性淋巴细胞白血病/儿童/地塞米松/泼尼松Key words
Acute lymphoblastic leukemia/Child/Dexamethasone/Prednisone分类
医药卫生引用本文复制引用
范小菊,李艳红,李争,冯小燕..地塞米松与泼尼松诱导缓解治疗中高危ALL患儿的效果比较[J].中国医学创新,2026,23(24):17-21,5.基金项目
江西省卫生健康委科技计划项目(202311038) （202311038）
