中国中医基础医学杂志2026，Vol.32Issue(9)：2026-2030,5.
薏苡仁调控肠-肌肉轴干预类风湿肌少症的作用机制
Mechanism of Action of Yiyiren in Modulating the Gut-Muscle Axis for Intervention in Rheumatoid Arthritis-Associated Sarcopenia
摘要
Abstract
Sarcopenia,a common complication of rheumatoid arthritis(RA),significantly elevates risks of joint dysfunction,falls,fractures,and mortality in RA patients,severely impairing overall health status,quality of life,and long-term prognosis.This review examines advancements in treating RA-associated sarcopenia with Yiyiren through the gut-microbiota-muscle relationship.In traditional Chinese medicine,RA-sarcopenia is classified within flaccidity syndrome,consumptive disease,and muscular atrophy categories.Anchored in traditional Chinese medicine theories that"the spleen governs transportation and transformation"and"the spleen associates with muscles",therapeutic strategies targeting the spleen align with the modern gut-muscle axis concept.Yiyiren,recognized for fortifying the spleen,resolving dampness,and alleviating arthralgia,modulates gut dysbiosis and enhances beneficial fatty acid production.These actions suppress inflammation,enhance mitochondrial function,regulate intramuscular lipid metabolism,and reduce insulin resistance.This multi-target,multi-level regulatory mechanism underscores its potential for preventing and treating RA-sarcopenia.关键词
类风湿关节炎/肌少症/肠-肌肉轴/肠道菌群/薏苡仁Key words
Rheumatoid arthritis/Sarcopenia/Gut-muscle axis/Gut microbiota/Yiyiren分类
医药卫生引用本文复制引用
刘嘉方,任爽,张杰..薏苡仁调控肠-肌肉轴干预类风湿肌少症的作用机制[J].中国中医基础医学杂志,2026,32(9):2026-2030,5.基金项目
国家自然科学基金项目(82104828) （82104828）
辽宁省科技计划联合计划(应用基础研究项目)(2023JH2/101700238) （应用基础研究项目）
"兴辽英才计划"医学名家项目(YXMJ-QNMZY-10,YXMJ-MZY-12) （YXMJ-QNMZY-10,YXMJ-MZY-12）
