中国中医眼科杂志2026，Vol.36Issue(9)：809-814,827,7.DOI:10.13444/j.cnki.zgzyykzz.2026.09.002
疏肝清热明目方熏蒸治疗Phaco联合IOL植入术后角膜损伤的疗效观察
Therapeutic Observation of Shugan Qingre Mingmu Formula Fu-migation on Corneal Injury after Phacoemulsification Combined with Intraocular Lens Implantation
摘要
Abstract
OBJECTIVE To observe the clinical efficacy of Shugan Qingre Mingmu Formula fumigation in the treatment of corneal injury after phacoemulsification combined with intraocular lens implantation(Phaco+IOL).METHODS A total of 71 patients(71 eyes)with corneal injury after Phaco+IOL admitted to Dongzhimen Hospital of Beijing University of Chinese Medicine from September 2024 to January 2025 were enrolled and randomly divided into a combination group(CG)of 36 cases(36 eyes)and a western medicine group(WMG)of 35 cases(35 eyes).The patients of WMG were treated with tobramycin dexamethasone eye drops and recombinant bovine basic fibroblast growth factor eye gel after surgery for 21 days,while the patients of CG received Shugan Qingre Mingmu Formula fumigation for 14 days starting from the 7th day after surgery on the basis of WMG treatment.The best corrected visual acuity(BCVA),central corneal thickness(CCT),tear film break-up time(BUT),corneal endothelial cell density(ECD),and Traditional Chinese Medicine(TCM)syndrome scores were measured before treatment,14 days after treatment,and three months after treatment.RESULTS(1)BCVA(LogMAR):The interaction effect between time and group was statistically significant(P＜0.05),while the group effect and time effect were not statistically significant(P＞0.05).BCVA(LogMAR)in the CG at 14 days and three months after treatment were better than that before treatment,with statistically significant differences(P＜0.05).There were no statistically significant differences in the WMG between 14 days and three months after treatment and before treatment,and no statistically significant differences between the two groups at each time point after treatment(P＞0.05).(2)CCT:The time effect and the interaction effect between time and group were statistically significant(P＜0.05),while the group effect was not statistically significant(P＞0.05).CCT in the CG at 14 days and three months after treatment were thinner than those before treatment,and CCT in the WMG at three months after treatment were thinner than those before treatment,with statistically significant differences(P＜0.05).There was no statistically significant difference in CCT in the WMG between 14 days after treatment and before treatment(P＞0.05).There were no statistically significant differences between the two groups at each time point after treatment(P＞0.05).(3)BUT:The time effect,group effect,and interaction effect between time and group were all statistically significant(P＜0.05).BUT in both groups at 14 days and three months after treatment were longer than those before treatment,with statistically significant differences(P＜0.05).BUT in the CG at 14 days and three months after treatment were longer than those in the WMG,with statistically significant differences(P＜0.05).(4)ECD:The time effect,group effect,and interaction effect between time and group were all statistically significant(P＜0.05).ECD in the WMG at three months after treatment were lower than those before treatment,with a statistically significant difference(P＜0.05).There were no statistically significant differences in ECD in the CG between 14 days and three months after treatment and before treatment,and no statistically significant difference in ECD in the WMG between 14 days after treatment and before treatment(P＞0.05).There was no statistically significant difference in ECD between the CG and the WMG at 14 days after treatment(P＞0.05),while ECD in the CG was higher than that in the WMG at three months after treatment,with a statistically significant difference(P＜0.05).(5)TCM syndrome scores:The group effect,time effect,and interaction effect between time and group were all statistically significant(P＜0.05).The TCM syndrome scores in both groups at 14 days and three months after treatment were lower than those before treatment,with statistically significant differences(P＜0.05).The TCM syndrome scores in the CG at 14 days and three months after treatment were lower than those in the WMG,with statistically significant differences(P＜0.05).CONCLUSIONS Fumigation with Shugan Qingre Mingmu Formula shows good efficacy in treating corneal injury after cataract surgery and can be recommended for clinical use.关键词
白内障/手术治疗/角膜损伤/中药熏蒸/应用效果Key words
cataract/surgical treatment/corneal injury/Traditional Chinese Medicine fumi-gation/application effect分类
医药卫生引用本文复制引用
张文硕,王养忠,孙珂,蔡文静,赵颖,严逸娴,吴羽纶,马悦,张冠婷,张国婷..疏肝清热明目方熏蒸治疗Phaco联合IOL植入术后角膜损伤的疗效观察[J].中国中医眼科杂志,2026,36(9):809-814,827,7.基金项目
1北京市通州区科技计划项目(KJ2024CX002)2北京中医药大学新教师基金项目(2024-JYB-XJSJJ-039)3北京中医药大学揭榜挂帅项目(2024-JYB-JBZD-033) （KJ2024CX002）
