中华耳科学杂志2026，Vol.24Issue(9)：850-854,5.DOI:10.3969/j.issn.1672-2922.2026.09.004
耳鸣与焦虑症的共病遗传基因研究
A genetic study of comorbidity between tinnitus and anxiety disorders
郭珍 1刘奕彤 1林勇1
作者信息
- 1. 成都市郫都区中医医院耳鼻喉科,成都 611730
- 折叠
摘要
Abstract
Objective Tinnitus and anxiety are clinically associated,but their genetic correlation remains unclear.This study aims to explore genetic associations between tinnitus and anxiety and identify shared genetic architecture.Methods A series of genetic analyses were conducted using data from two large genome-wide association studies(GWAS).Linkage disequilibrium score regression was used to calculate genetic correlations,while multi-trait analysis of GWAS and cross-phenotype association analysis were employed to identify cross-trait shared genetic variants.Gene annotation was performed using multi-marker analysis of GenoMic Annotation and Annotation of genetic Variants(ANNOVAR).Results A positive genetic correlation between tinnitus and anxiety was identified,with 14 shared genetic variants(including 10 causal variants)and 6 prioritized shared genes.Conclusions A positive genetic correlation exists between tinnitus and anxiety,and both conditions share certain genetic variants and loci.关键词
耳鸣/焦虑症/遗传关联/遗传结构Key words
tinnitus/anxiety/genetic association/genetic structure引用本文复制引用
郭珍,刘奕彤,林勇..耳鸣与焦虑症的共病遗传基因研究[J].中华耳科学杂志,2026,24(9):850-854,5.
