中华耳科学杂志2026，Vol.24Issue(9)：894-900,7.DOI:10.3969/j.issn.1672-2922.2026.09.011
爆震对小型猪皮质听觉诱发电位P1-N1-P2波形特征影响的分析
Effects of blast exposure on waveform characteristics of cortical auditory evoked potentials P1-N1-P2 in miniature pigs
摘要
Abstract
Objective To report time-course changes of cortical auditory evoked potentials(CAEPs)P1-N1-P2 in miniature pigs after blast exposure.Methods Fourteen miniature pigs with normal hearing were randomly assigned to receive blast exposure(n=10)or serve as controls(no blast exposure,n=4).Auditory brainstem response(ABR)thresholds,as well as the latency and amplitude of CAEP P1-N1-P2,were recorded at baseline(before blast exposure)and 1,2,4,and 8 weeks after blast exposure,followed by statistical analysis.Results Hearing loss was induced in 8 pigs in the exposure group.There was no significant difference in baseline ABR thresholds and P1-N1-P2 parameters between the two groups(P>0.05).In the exposure group,ABR thresholds increased by≥40 dB SPL immediately after blast exposure,and remained significantly higher than baseline and the control group by the 8th week(P<0.05)despite partial recovery and a trend to stabilize.There was no significant change in ABR threshold at all times in the control group(P>0.05).CAEP P1-N1-P2 were not detectable immediately after blast exposure,but detectable in all animals 1 week after blast exposure,although with progressive prolongation of latency and decrease in amplitude.CAEP P1-N1-P2 parameters remained unchanged in the control group(P>0.05),significantly different from the exposure group at all time points(P<0.05).Conclusions Blast exposure can cause persistent changes CAEP P1-N1-P2 abnormality in miniature pigs.Despite signs of partial recovery,central auditory system dysfunction persists during the observation period with diminishing trend of continued recovery.关键词
小型猪/噪声性聋/爆震性聋/皮质听觉诱发电位/听皮质/功能Key words
miniature pigs/noise-induced hearing loss/blast-induced hearing loss/cortical auditory evoked potential/auditory cortex/function引用本文复制引用
钟旻璇,杨崇灵,唐菲,郭维维,杨仕明,吕萍,刘军..爆震对小型猪皮质听觉诱发电位P1-N1-P2波形特征影响的分析[J].中华耳科学杂志,2026,24(9):894-900,7.基金项目
国家自然科学基金项目(82371148) （82371148）
解放军总医院临床科研扶持基金课题(2012FC-TSYS-4017) （2012FC-TSYS-4017）
解放军总医院科技创新基金项目(06ZY13) （06ZY13）
北京市科技计划首都市民健康项目培育基金(Z131100004013019) （Z131100004013019）
四川省重点研发计划(2023YFG0282) （2023YFG0282）
