肿瘤防治研究2026，Vol.53Issue(8)：577-588,12.DOI:10.3971/j.issn.1000-8578.2026.26.0002
精准医学时代EGFR突变阳性非小细胞肺癌的全程管理:学习型MDT体系的构建与优化
Comprehensive Management of EGFR Mutation-Positive Non-Small Cell Lung Cancer in the Era of Precision Medicine:Construction and Optimization of A Learning-Oriented Multidisciplinary Team System
摘要
Abstract
In the era of precision medicine,therapeutic strategies for epidermal growth factor receptor(EGFR)mutation-positive non-small cell lung cancer(NSCLC)have become increasingly advanced.However,conventional multidisciplinary team(MDT)models fail to address the demands of dynamic whole-course disease management.This review proposes an evolved learning-oriented MDT system for the standardized management of EGFR mutation-positive NSCLC.Grounded in evidence-based medicine,centered on expert decision-making,and supported by digital integration,this system enables the comprehensive evaluation of patients'individual characteristics,including performance status,psychosocial conditions,and economic affordability.This article elucidates the core management objectives and key PICO-style clinical questions for EGFR mutation-positive NSCLC across critical disease stages,including resect-able early-stage disease,stage Ⅲ disease,metastatic/oligoprogressive disease,and tyrosine kinase inhibitor-resistant disease.Based on updated quantitative clinical evidence,we develop a structured framework for the learning-oriented MDT system,covering a multidimensional collaborative structure,standardized node-based workflows,a full-cycle inf-ormation integration platform,quantita-tive evaluation indicators,and a closed-loop optimization mechanism.Notably,we propose a multicenter prospective randomized controlled trial design to validate the clinical efficacy of this system.This review analyzes the imple-mentation limitations and potential soc-ial impacts of the system and proposes phased optimization and mitigation stra-tegies.This work provides a theoretical framework and practical guidance for establishing a stand-ardized,precise,and humanistic whole-course management model for EGFR mutation-positive NSCLC.关键词
精准医学/EGFR突变/非小细胞肺癌/学习型多学科团队/全程管理/循证决策Key words
Precision medicine/EGFR mutation/Non-small cell lung cancer/Learning-oriented multidisciplinary team/Comprehensive management/Evidence-based decision-making分类
医药卫生引用本文复制引用
吕丽,李美仙,林劼..精准医学时代EGFR突变阳性非小细胞肺癌的全程管理:学习型MDT体系的构建与优化[J].肿瘤防治研究,2026,53(8):577-588,12.基金项目
国家自然科学基金(82160453) （82160453）
云南省高层次卫生健康技术人才医学学科后备人才(H-2024090) （H-2024090）
昆明医科大学第二附属医院2023年人才梯队培育项目(RCTDHB-202306,RCTDXK-202304) National Natural Science Foundation of China(No.82160453) （RCTDHB-202306,RCTDXK-202304）
High-Level Medical and Health Technical Talents and Medical Discipline Reserve Talents in Yunnan Province(No.H-2024090) （No.H-2024090）
The 2023 Talent Development Project of the Second Affiliated Hospital of Kunming Medical University(No.RCTDHB-202306,No.RCTDXK-202304) （No.RCTDHB-202306,No.RCTDXK-202304）
