肿瘤防治研究2026，Vol.53Issue(8)：616-624,9.DOI:10.3971/j.issn.1000-8578.2026.26.0046
癌性厌食的病理机制与诊疗进展
Pathogenic Mechanisms and Advances in Diagnosis and Treatment of Cancer-Related Anorexia
摘要
Abstract
Cancer-related anorexia(CRA)is a common and severe complication of malignant tumors.It is characterized by persistent appetite loss,early satiety,and reduced food intake.It directly leads to malnutrition,decreased treatment tolerance,reduced quality of life,and worsened prognosis.Its pathogenesis is complex,involving a multilayered network of interactions,including the dysregulation of the hypothalamic feeding center,imbalance of peripheral appetite hormones and systemic inflammatory mediators,and actions of tumor-derived factors.It is also highly influenced by anticancer treatments,such as chemotherapy,radiotherapy,and surgery.Current clinical management is dominated by multimodal comprehensive therapy based on progestogens,glucocorticoids and prokinetic agents,combined with nutritional support,rehabilitation exercise,psychological intervention and traditional Chinese medicine.However,highly effective approaches capable of fundamentally reversing the disease course of CRA are still lacking.This article provides a systematic review of the pathophysiological mechanisms,clinical assessment tools,and comprehensive treatment strategies for CRA.It also presents a discussion on future research directions based on the latest advances to provide a theoretical basis and reference for optimizing clinical practice and developing novel intervention strategies.关键词
癌性厌食/发病机制/诊断/综合治疗Key words
Cancer-related anorexia/Pathogenesis/Diagnosis/Comprehensive treatment分类
医药卫生引用本文复制引用
刘泽豪,徐淼,薛鹏,朱世杰,谢飞宇..癌性厌食的病理机制与诊疗进展[J].肿瘤防治研究,2026,53(8):616-624,9.基金项目
National Natural Science Foundation of China(No.82505692) （No.82505692）
Joint Project of Traditional Chinese Medicine Science and Technology in the National Comprehensive Reform Demonstration Zone of Traditional Chinese Medicine(No.2025ZR009) （No.2025ZR009）
China Postdoctoral Science Foundation General Project(No.2025M783903) 国家自然科学基金(82505692) （No.2025M783903）
国家中医药综合改革示范区中医药科技共建项目(2025ZR009) （2025ZR009）
中国博士后面上项目(2025M783903) （2025M783903）
