中南民族大学学报（自然科学版）2026，Vol.45Issue(6)：796-805,10.DOI:10.20056/j.cnki.ZNMDZK.20260744
树苔浸膏化学成分及其抗菌活性的网络药理学研究
Chemical constituents and antibacterial mechanisms of treemoss concrete by network pharmacology
摘要
Abstract
To investigate the chemical constituents and antibacterial activity of moss extract,separation techniques such as silica gel column chromatography,gel chromatography,and high-performance liquid chromatography(HPLC),along with modern spectroscopic methods(NMR,MS),were employed for the isolation,purification,and structural characterization of the chemical components.Network pharmacology was utilized to predict the synergistic targets and pathways of the antibacterial effects,which were preliminarily validated through molecular docking and in vitro antibacterial assays.Eleven compounds were isolated from the moss extract and identified as:mossol(1),2-methylmossol(2),5-propylbenz-1,3-diol(3),4-methylmossol(4),ethyl ester of mossol carboxylic acid(5),atraric acid(6),mossol aldehyde(7),diffractaic acid(8),8-[2,4-dihydroxy-6-(2-oxoheptyl)-phenoxy]-6-hydroxy-3-pentyl-1H-isochromen-1-one(9),8-(2,4-dihydroxy-6-pentylphenoxy)-6-hydroxy-3-pentyl-1H-isochromen-1-one(10),and 8-[2,4-dihydroxy-6-(2-oxoheptyl)phenoxy]-6-methoxy-3-pentyl-1H-isochromen-1-one(11).Through screening the SwissADME database,eight potential active ingredients were identified.Network pharmacology results indicate that these components may act on key targets such as ALB,TNF,and MMP9 via biological processes including extracellular space responses to exogenous stimuli,exerting antibacterial effects through mechanisms like the IL-17 signaling pathway and Th17 cell differentiation.In vitro antibacterial experiments revealed that multiple constituents in tree moss extract exhibited definite antibacterial activity,with selective antibacterial spectra.关键词
树苔浸膏/成分鉴定/抗菌/网络药理学Key words
treemoss concrete/component identification/antibacterial/network pharmacology分类
医药卫生引用本文复制引用
乃比江·麦图荪,杜道全,阿吉尔古丽·麦麦提,阿米娜·苏来曼,买买提江·阿布都瓦克,杨新洲..树苔浸膏化学成分及其抗菌活性的网络药理学研究[J].中南民族大学学报（自然科学版）,2026,45(6):796-805,10.基金项目
新疆第二批"天山英才"项目(2023TSYCJC0048) （2023TSYCJC0048）
新疆"天池英才"引进计划高校特聘教授项目 （）
