中医药学报2026，Vol.54Issue(9)：60-64,5.DOI:10.19664/j.cnki.1002-2392.260181
十味升血汤干预进展期非小细胞肺癌恶病质(气血两虚证)的前瞻性队列研究
A Prospective Cohort Study on the Intervention of Shiwei Shengxue Decoction in Advanced Non-Small-Cell Lung Cancer with Cachexia(Qi and Blood Deficiency Syndrome)
摘要
Abstract
Objective:To investigate the efficacy and safety of Shiwei Shengxue Decoction in improving the nutritional status of patients with advanced non-small cell lung cancer(NSCLC)cachexia(Qi and Blood Deficiency Syndrome).Methods:A prospective cohort study design was adopted.Patients with advanced NSCLC who met the diagnostic criteria for Qi and Blood Deficiency Syndrome and cancer cachexia,admitted to Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,and Shunyi Hospital,Beijing Hospital of Traditional Chinese Medicine,from March 2023 to March 2024,were enrolled.Based on whether they received Shiwei Shengxue Decoction(treatment for≥4 weeks),patients were naturally assigned to an exposed group and a non-exposed group.Both groups received conventional nutritional treatment.Results:After propensity score matching(PSM),45 pairs of patients were included.The total effective rate for improving nutritional status in the exposed group was 77.8%(35/42),which was significantly higher than that in the non-exposed group(48.9%,22/45),with a statistically significant difference(P<0.05).The exposed group showed superior improvements in increasing food intake,maintaining body weight,enhancing grip strength,and raising serum hemoglobin(Hgb)levels compared to the non-exposed group(P<0.05).However,no statistically significant differences were observed in KPS scores or serum albumin(ALB)levels between the two groups(P>0.05).No adverse events were reported during the study period.Conclusion:Shiwei Shengxue Decoction can effectively improve the nutritional status of patients with advanced NSCLC cachexia(Qi and Blood Deficiency Syndrome)with a favorable safety profile.关键词
进展期非小细胞肺癌/营养状况/恶病质/十味升血汤/队列研究Key words
Advanced non-small cell lung cancer/Nutritional status/Cachexia/Shiwei Shengxue Decoction/Cohort study分类
医药卫生引用本文复制引用
张旭,杨国旺,佟丽,栗琼洋,袁怿,马艳新,张驰,杜霄..十味升血汤干预进展期非小细胞肺癌恶病质(气血两虚证)的前瞻性队列研究[J].中医药学报,2026,54(9):60-64,5.基金项目
国家自然科学基金青年基金项目(82405507) （82405507）
北京中医医院院级课题暨两院合作课题(LYYB202217) （LYYB202217）
北京市属医院科研培育计划项目(PZ2024029) （PZ2024029）
北京中医医院院级青年职工创新工作室项目(2025-013) （2025-013）
