中医药学报2026，Vol.54Issue(9)：116-120,5.DOI:10.19664/j.cnki.1002-2392.260191
半夏泻心汤对局部进展期胃癌术后SOX方案化疗患者免疫及营养状态的影响
Effects of Banxia Xiexin Decoction on Immune and Nutritional Status in Patients with Locally Advanced Gastric Cancer Receiving Postoperative SOX Regimen Chemotherapy
摘要
Abstract
Objective:To explore and analyze the application effect of Banxia Xiexin Decoction on patients with locally advanced gastric cancer during postoperative SOX regimen chemotherapy,and to analyze its influence on immunity and nutritional status of patients.Methods:A total of 118 patients with locally advanced gastric cancer who visited department of gastrointestinal surgery of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from May 2021 to May 2024 were included.They were randomly divided into the conventional group and the combined group using a random number table(simple random grouping method),with 59 cases in each group.The patients in the conventional group received SOX regimen chemotherapy after surgery,whereas the patients in the combined group were added with Banxia Xiexin Decoction.The changes of tumor factors,immune factors,gastrointestinal function and nutritional indicators were observed in the two groups after treatment.Results:After treatment,the levels of carcinoembryonic antigen,vascular endothelial growth factor,matrix metalloproteinase-9 and other tumor factors in the combined group were lower than those in the conventional group(P<0.05).The levels of diamine oxidase and fecal calprotectin in the combined group were lower while the level of motilin was higher compared to the conventional group(P<0.05).The neutrophil-to-lymphocyte ratio and interleukin-6 in the combined group were lower compared with those in the conventional group while the proportion of CD8+T was higher(P<0.05).The levels of albumin,prealbumin and transferrin and body mass in the combined group were higher than those in the conventional group(P<0.05).In terms of treatment safety,the incidence rates of adverse chemotherapy reactions were lower in the combined group compared to the conventional group(P<0.05).Conclusion:Banxia Xiexin Decoction can reduce the levels of tumor factors,promote the improvements of gastrointestinal function,immunity and nutritional status,and play a role in reducing toxicity and increasing efficiency in patients with locally advanced gastric cancer receiving SOX regimen chemotherapy after surgery.关键词
进展期胃癌/半夏泻心汤/化疗/免疫/营养Key words
Advanced gastric cancer/Banxia Xiexin Decoction/Chemotherapy/Immunity/Nutrition分类
医药卫生引用本文复制引用
胡建,龚航军,韩刚,曹羽,张云,张言言,张旭..半夏泻心汤对局部进展期胃癌术后SOX方案化疗患者免疫及营养状态的影响[J].中医药学报,2026,54(9):116-120,5.基金项目
上海市科学技术委员会科研计划项目(19401973000) （19401973000）
