生物资源2026，Vol.48Issue(4)：409-418,10.DOI:10.14188/j.ajsh.20260004
管花肉苁蓉食用安全性评价研究
Study on edible safety evaluation of Cistanche tubulosa
摘要
Abstract
Cistanche tubulosa(Schenk)Wight,a perennial herbaceous plant of the Orobanchaceae family,has a long history of application in China.However,its industrial development is severely restricted due to its exclusion from the national food ingredient catalog.To verify its edible safety,this study systematically evaluated the safety of C.tubulosa according to relevant national standards and regulations.The evaluation included acute oral toxicity tests(in mice and rats),three genotoxicity tests,and a 90-day oral feeding toxicity test in rats.The results showed that the median lethal dose(LD50)of C.tubulosa was>10 g/(kg·bw)for both male and female mice and rats,indicating that it belongs to the non-toxic grade.The bacterial reverse mutation test yielded negative results at all dose groups.In the mammalian erythrocyte micronucleus test,no significant differences(P>0.05)in micronucleus cell rates were observed between the female and male mice in each dose group and the solvent control group.The in vitro mammalian cell chromosome aberration test also showed negative results.In the 90-day oral toxicity test followed by a 28-day observation period,rats were fed diets containing the test substance at concentrations of 100,50,and 25 g/kg feed,and no delayed toxic reactions were observed throughout the experiment.In conclusion,under the conditions of this study,C.tubulosa exhibited no acute toxicity,genotoxicity or subacute toxicity,demonstrating a favorable safety profile.These findings provide experimental evidence for the addition of C.tubulosa to the national list of food and medicinal substances,as well as for its widespread application in functional foods and health products.关键词
管花肉苁蓉/急性经口毒性/遗传毒性/90 d经口毒性Key words
Cistanche tubulosa(Schenk)Wight/acute oral toxicity/genotoxicity/90-day oral toxicity分类
农业科技引用本文复制引用
赵丽,李小万,石磊岭,刘杨,李秀荣,孙宇,卿德刚..管花肉苁蓉食用安全性评价研究[J].生物资源,2026,48(4):409-418,10.基金项目
新疆维吾尔自治区重大专项(2023A03005-4) （2023A03005-4）
昌吉州"庭州英才"育才计划项目(纵20250045) （纵20250045）
