波谱学杂志2026，Vol.43Issue(3)：279-290,12.DOI:10.11938/cjmr20253189
19F NMR化学位移编码的cRGD靶向双模态探针多色成像
19F NMR Chemical Shift-encoded cRGD-targeted Dual-modal Probe for Multicolor Imaging
摘要
Abstract
Specific imaging of the tumor microenvironment is critical for precise cancer diagnosis,yet conventional single-modal imaging techniques struggle to combine high sensitivity with high spatial resolution.This study designed and synthesized a cRGD peptide-targeted,nitroreductase(NTR)-responsive hemicyanine-19F dual-modal probe,Cy-F-cRGD.Through systematic screening of different fluorine-containing groups,we found that an ortho-difluoro structure induced a remarkable 19F chemical shift change(ΔδF=10.87).Concurrently,the hemicyanine unit exhibited an 80 nm red shift in absorption and a 90-fold fluorescence enhancement,achieving an optical"off-on"signal switch.This work offers a new design strategy for developing smart responsive multimodal probes.关键词
磁共振成像/双模态探针/硝基还原酶/半花菁/19F化学位移Key words
magnetic resonance imaging(MRI)/dual-modal probe/nitroreductase/hemicyanine/19F chemical shift分类
数理科学引用本文复制引用
李娜,肖龙,李莎,刘昱墩,贾宇舒,张磊,陈世桢..19F NMR化学位移编码的cRGD靶向双模态探针多色成像[J].波谱学杂志,2026,43(3):279-290,12.基金项目
国家自然科学基金项目(U21A20392,82127802,22404064,82102125) （U21A20392,82127802,22404064,82102125）
湖北省自然科学基金项目(2023BCB092) （2023BCB092）
中国科学院青年跨学科团队项目(JCTD-2022-13). （JCTD-2022-13）
