波谱学杂志2026，Vol.43Issue(3)：339-349,11.DOI:10.11938/cjmr20263198
恩塞芬汀核磁共振波谱学数据解析
Detailed NMR Assignment of Ensifentrine
摘要
Abstract
Ensifentrine was approved for marketing by the U.S.Food and Drug Administration(FDA)in June 2024.To date,however,the literature has provided only the raw NMR spectral data of this drug without detailed signal assignments,which hinders impurity identification and quality control for ensifentrine.Furthermore,the compound contains multiple quaternary carbon and nitrogen atoms,presenting challenges in assigning NMR signals.In this study,we employed a Bruker Avance III 400 MHz NMR spectrometer to acquire 1H,13C,and two-dimensional NMR spectra of ensifentrine,and fully assigned all 1H and 13C signals.Notably,unlike previous reports,we utilized DMSO-d6 as the solvent,which enhanced sample solubility,permitted unambiguous identification of the coupling relationships of active hydrogen signals,and yielded well-resolved two-dimensional NMR spectra.This work provides a reference for NMR-based structural analysis,content determination,and quality control of the active pharmaceutical ingredient(API)ensifentrine.关键词
恩塞芬汀/结构解析/核磁共振/二维核磁共振Key words
ensifentrine/structural analysis/nuclear magnetic resonance(NMR)/two-dimensional NMR spectroscopy分类
数理科学引用本文复制引用
潘美红,秦楠,赵川,文柳静..恩塞芬汀核磁共振波谱学数据解析[J].波谱学杂志,2026,43(3):339-349,11.基金项目
天津医科大学基础医学院青年教师科研孵育基金项目(2023FY04) （2023FY04）
天津医科大学肿瘤医院药物成药性评价与系统转化全国重点实验室资助项目(QZ23-5和QZKF24-5). （QZ23-5和QZKF24-5）
