磁共振成像2026，Vol.17Issue(9)：49-54,6.DOI:10.12015/issn.1674-8034.2026.09.007
基于多模态MRI的肥胖儿童大脑结构与功能协同变化分析
Analysis of coordinated changes in brain structure and function in obese children based on multimodal MRI
摘要
Abstract
Objective:To investigate the coordinated changes in brain structure and function in obese children,providing imaging evidence for understanding the effects of obesity on pediatric neurodevelopment.Materials and Methods:This study was a prospective case-control study,consecutively enrolling 46 obese children aged 8 to 14 years and 48 children of normal weight.Multimodal MRI scanning was performed using a 3.0 T scanner,including three-dimensional T1-weighted imaging(3D-T1WI),diffusion tensor imaging(DTI),and resting-state functional MRI(rs-fMRI),to compare differences in gray and white matter volumes,white matter integrity,and functional network connectivity between the two groups.Results:Compared with control group,the obese group showed significantly reduced volumes in prefrontal cortex and hippocampus(P<0.001),and significantly increased volumes in the striatum and orbitofrontal cortex(P<0.001).DTI showed significantly decreased fractional anisotropy values in the corpus callosum and internal capsule in the obese group(P<0.001).Functional analysis revealed altered network connectivity in the obese group,with enhanced connectivity within reward and default mode networks and weakened connectivity within the executive control network(P<0.001).Structural and functional changes were significantly correlated(r=0.58 to 0.65,P<0.001).Conclusions:This study suggests that obese children may exhibit a coordinated patterns of reduced volume in cognitive control regions accompanied by reward system hyperactivation.Multimodal MRI may help elucidate the associations between obesity and structural and functional brain alterations in children,providing imaging clues for the early identification and precision intervention of obesity-related neurodevelopmental disorders.关键词
肥胖/儿童/磁共振成像/脑结构/脑功能Key words
obesity/children/magnetic resonance imaging/brain structure/brain function分类
医药卫生引用本文复制引用
李倩,赵俊,王心,王瑞珠..基于多模态MRI的肥胖儿童大脑结构与功能协同变化分析[J].磁共振成像,2026,17(9):49-54,6.基金项目
国家自然科学基金项目(编号:82101999)National Natural Science Foundation of China(No.82101999). （编号:82101999）
