磁共振成像2026，Vol.17Issue(9)：55-61,68,8.DOI:10.12015/issn.1674-8034.2026.09.008
自闭症谱系障碍患者静态与动态低频振幅异常及其与多巴胺/5-羟色胺系统的空间相关性分析
Abnormalities in static and dynamic amplitude of low-frequency fluctuations and their spatial correlations with the dopamine/5-hydroxytryptamine systems in patients with autism spectrum disorder
摘要
Abstract
Objective:To investigate the abnormal characteristics of static amplitude of low-frequency fluctuations(sALFF)and dynamic amplitude of low-frequency fluctuations(dALFF)in resting-state functional magnetic resonance imaging(rs-fMRI)among adolescents with autism spectrum disorder(ASD),and to analyze their associations with clinical symptoms and the distribution of neurotransmitter systems.Materials and Methods:This was a retrospective case-control study.Fifty-seven adolescents with ASD and 71 age-and sex-matched healthy controls(HC)were retrospectively screened from the Autism Brain Imaging Data Exchange(ABIDE)database as study subjects.After standard preprocessing,whole-brain sALFF and dALFF(calculated using a sliding-window approach)were derived.After controlling for age,gender,mean framewise displacement,and full-scale IQ,two-sample t-tests were performed for intergroup comparisons,followed by Gaussian Random Field(GRF)correction.Pearson correlation analyses were conducted to assess relationships between altered brain activity and stereotyped behavior scores from the Autism Diagnostic Observation Schedule(ADOS).Spatial correlation analyses between case-control difference maps and templates of 10 neurotransmitter receptors/transporters were performed using the JuSpace toolbox with correction for multiple comparisons.Results:Compared with the HC group,the ASD group exhibited significantly decreased sALFF in the left medial orbital superior frontal gyrus(peak t=-4.347,GRF corrected,P<0.05)and significantly increased dALFF in the left middle frontal gyrus(peak t=4.429,GRF corrected,P<0.05)and orbital part of the left middle frontal gyrus(peak t=5.327,GRF corrected,P<0.05).The reduced sALFF in the left medial orbital superior frontal gyrus showed a positive correlational trend with ADOS stereotyped behavior scores(r=0.263,uncorrected P=0.048),while increased dALFF in the orbital part of the left middle frontal gyrus showed a stronger positive correlation trend(r=0.294,uncorrected P=0.026).Spatial correlation analysis revealed that sALFF alterations were negatively correlated with dopamine D1 receptor density(r=-0.73,q<0.01)and positively correlated with dopamine D2 receptor density(r=0.92,q<0.01).In contrast,dALFF alterations were positively correlated with serotonin 5-HT4 receptor(r=0.43,q<0.01)and dopamine D1 receptor density(r=0.42,q<0.01),and negatively correlated with serotonin 5-HT1a receptor(r=-0.23,q<0.05),dopamine D2 receptor density(r=-0.65,q<0.01)and 18F-FDOPA uptake distribution(r=-0.50,q<0.01).Conclusions:Adolescents with ASD exhibit distinct abnormalities in both static and dynamic local brain activity within the prefrontal cortex.Dynamic alterations show stronger associations with stereotyped behaviors.These functional abnormalities are closely related to dopaminergic and serotonergic systems,suggesting that dALFF may serve as a putative neuroimaging biomarker reflecting the neurobiological mechanisms of ASD.关键词
自闭症谱系障碍/静息态功能磁共振成像/磁共振成像/低频振幅/多巴胺受体/5-羟色胺受体/分子影像学Key words
autism spectrum disorder/resting-state functional magnetic resonance imaging/magnetic resonance imaging/amplitude of low-frequency fluctuations/dopamine receptors/serotonin receptors/molecular imaging分类
医药卫生引用本文复制引用
谭金莎,韩超,司雨宁,张淑婷,王梅云..自闭症谱系障碍患者静态与动态低频振幅异常及其与多巴胺/5-羟色胺系统的空间相关性分析[J].磁共振成像,2026,17(9):55-61,68,8.基金项目
国家自然科学基金项目(编号:82371934) （编号:82371934）
国家重点研发计划项目(编号:2023YFC2414200)National Natural Science Foundation of China(No.82371934) （编号:2023YFC2414200）
National Key R&D Program of China(No.2023YFC2414200). （No.2023YFC2414200）
